INSULIN RESISTANCE AND VASCULAR DYSFUNCTION IN ASIAN INDIANS

亚裔印度人的胰岛素抵抗和血管功能障碍

• 批准号: 7379267
• 负责人: annaswamy raji
• 金额: $ 0.38万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379267
• 关键词: INSULIN; RESISTANCE; VASCULAR; DYSFUNCTION; ASIAN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to investigate why Asian Indians are at a higher risk for developing diabetes and coronary heart disease compared to Caucasians living in the U.S. This study will test the hypothesis that Asian Indians are insulin resistant, exhibit altered body fat distribution and have endothelial dysfunction compared to Caucasians matched for age and BMI. We will also determine whether insulin sensitizers can improve insulin resistance and reverse the endothelial dysfunction in Asian Indians compared to Caucasians matched for age and BMI.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。本研究的目的是调查为什么亚裔印度人与居住在美国的白种人相比，患糖尿病和冠心病的风险更高。这项研究将检验以下假设：与年龄和 BMI 匹配的白种人相比，亚裔印度人存在胰岛素抵抗、体脂分布改变以及内皮功能障碍。我们还将确定与年龄和体重指数匹配的白人相比，胰岛素增敏剂是否可以改善亚洲印度人的胰岛素抵抗并逆转内皮功能障碍。