INFANT HEART SURGERY: CNS SEQUELAE OF HEMATOCRIT MANAGEMENT

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。迄今为止，临床研究尚未确定在婴儿心脏直视手术期间用于支持重要器官的低温低流量心肺转流和全循环停搏之前冷却期间的最佳血液稀释程度。本初步研究的目的是为未来的前瞻性随机临床试验提供数据，比较在心肺转流冷却阶段，循环停止或低流量之前，接受修复性心脏直视手术的婴儿和儿童的两种红细胞压积管理策略的神经和发育结局。我们的目标将在一项前瞻性、随机、单中心试验中实现。治疗策略将在神经系统参数方面进行比较。将在12个月时评估居住在当地的患者的神经和发育结局。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Clinical studies to date have not determined the optimal degree of hemodilution during cooling prior to hypothermic low-flow cardiopulmonary bypass and total circulatory arrest used to support vital organs during reparative open heart surgery in infants. The purpose of the present pilot study is to provide data for a future prospective randomized clinical trial comparing neurologic and developmental outcome of two strategies of hematocrit management during the cooling phase of cardiopulmonary bypass, prior to circulatory arrest or low-flow, in infants and children undergoing reparative open heart surgery. Our goals will be pursued in a prospective, randomized, single-center trial. The treatment strategies will be compared with respect to neurologic parameters. Neurologic and developmental outcomes will be assessed at 12 months in those patients who live locally.