INFANT HEART SURGERY: CNS SEQUELAE OF HEMATOCRIT MANAGEMENT

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Clinical studies to date have not determined the optimal degree of hemodilution during cooling prior to hypothermic low-flow cardiopulmonary bypass and total circulatory arrest used to support vital organs during reparative open heart surgery in infants. The purpose of the present pilot study is to provide data for a future prospective randomized clinical trial comparing neurologic and developmental outcome of two strategies of hematocrit management during the cooling phase of cardiopulmonary bypass, prior to circulatory arrest or low-flow, in infants and children undergoing reparative open heart surgery. Our goals will be pursued in a prospective, randomized, single-center trial. The treatment strategies will be compared with respect to neurologic parameters. Neurologic and developmental outcomes will be assessed at 12 months in those patients who live locally.