RANDOMIZED, MULTICENTER TACROLIMUS WITH STEROID VS STEROID FREE (SNS-01)

随机、多中心他克莫司含类固醇与不含类固醇 (SNS-01)

• 批准号: 7380757
• 负责人: WILLIAM E. HARMON
• 金额: $ 1.99万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380757
• 关键词: RANDOMIZED; MULTICENTER; TACROLIMUS; STEROID; VS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study objective is to compare the safety and efficacy of a traditional steroid based-protocol (Prograf, MMF, steroids and standard daclizumab induction until the second month post-transplant) to a steroid-free protocol (Prograf, MMF and daclizumab induction until the sixth month post-transplant). Precise endpoint definition and power considerations are described in the statistical section of this protocol.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。研究目的是比较传统的基于类固醇的方案（直到移植后第二个月的DAF，MMF，类固醇和标准daclizumab诱导）与无类固醇方案（直到移植后第六个月的DAF，MMF和daclizumab诱导）的安全性和有效性。精确的终点定义和把握度考虑在本方案的统计学章节中描述。