INVESTIGATION OF FACIAL ASYMMETRY IN PATIENTS WITH CRANIOFACIAL ANOMALIES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的总体目的是颅面畸形患者颅面特征的表征。将唇腭裂患者与正常人群进行比较。面部的生长受到手术的影响——外科医生在解决这些孩子的三维缺陷时必须考虑到“第四维度”（时间）。因此，记录唇腭裂修复后几个面部标志的人体测量值随年龄的变化是很重要的。用卡尺和尺子进行客观测量可以有效地记录这些测量结果，但可能很耗时，而且需要专家才能获得。新兴的三维数字摄影测量技术可以帮助克服这些困难。我们建议，3D数字摄影测量技术将系统和定量地获得形态测量，以一种高效的方式，更好地定义颅面畸形患者的面部畸形。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The general aim of this study is characterization of craniofacial features in patients with craniofacial anomalies. Patients with cleft lip and palate will be compared with normal population. Growth of face is affected by surgery--a surgeon has to take into account the 'fourth dimension' (of time) while addressing three-dimensional defects in these children. Therefore, it is important to record changes in anthropometric measurements of several facial landmarks with age after repair of cleft lip and palate. Objective measurements with calipers and rulers are powerful to record such measurements, but can be time-consuming and require experts to obtain them. Newly emerging techniques in 3D digital photogrammetric techniques can help overcome these difficulties. We propose that 3D digital photogrammetric techniques will systematically and quantitatively obtain morphometric measurements in a time-efficient manner and better define facial dysmorphology in patients with craniofacial anomalies.