ATHEROSCLEROSIS AND NONINVASIVE DETERMINATION OF ENDOTHELIAL ACTIVITY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。获得冠状动脉疾病（CAD）、颈动脉（CA）和外周动脉闭塞性疾病（PAOD）患者内皮活性的非侵入性信息，并与健康对照受试者进行比较。将结果应用于一个大规模的无症状受试者的筛查计划，使用一种简单的方法，适合于常规办公室检查。因此，检测到内皮活性降低可能会发现无症状的受试者处于风险中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obtain non-invasive information on endothelial activity in patients with coronary artery disease (CAD), carotid artery (CA) and peripheral arterial occlusive disease (PAOD) which will be compared with that of healthy control subjects. Apply the results to a wide-scale screening program for symptom free subjects at risk using a simple methodology suitable for routine office examination. Detection of reduced endothelial activity may thus identify asymptomatic subjects at risk.