EXTREME DIETARY CARBOHYDRATE RESTRICTION EFFECT ON HEPATIC GLUCOSE PRODUCTION

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity and its associatd co-morbidities are among the most prevalent and challengin conditions confronting the medical profession in the 21st century. current dietary recommendations from the NIH for weight loss have historically proven difficult to initiate and maintain. Additionally, recommended diets for diabetic patients have proven effective in the short-term but fall short in aiding glycemic control in the long-term. The newly popular carbohydrate-restricted diet may offer benefits to those seeking weight reduction and improved glycemic control greater than those realized with a low-fat, high-carbohydrate, calorie-restricted diet. However, little is known about the effect of either of these diets on hepatic gluose metabolism. This study seeks to determine the impact of severe dietary carbohydrate restriction on hepatic glucose metabolism in terms of the sources of precursors for glucose produced by the liver (glycogen, glycerol, and pyruvate) and the flux of intermediates through the Krebs' cycle, postphoenolpyruvate carboxykinase, and pyruvate recycling. Identifying alterations in hepatic glucose metabolism will aid in the understanding of the benefits a carbohydrate-restricted diet may have and may aid in identification of those persons more likely to benefit from dietary carbohydrate restriction versus fat and calorie restriction (i.e., the ability to tailor a diet plan as opposed to the current one-sixe-fits-all approach).