HEPATIC CARBOHYDRATE METABOLISM IN THE YOUNG AND ELDERLY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的假设是，肝脏的葡萄糖输出随年龄增长而增加，继发于肝脏胰岛素抵抗，与体重或体力活动水平无关，从而导致老年人易患糖尿病或葡萄糖耐量受损。 本研究的目的是：1）量化年轻人和老年人空腹条件下的肝葡萄糖输出，以了解与衰老相关的葡萄糖稳态变化。2)以确定肝脏中葡萄糖合成的底物来源，并将该数据与肝脏葡萄糖产生相关联，作为检测中间代谢改变的手段，所述中间代谢改变可能是与年龄增长相关的代谢疾病（如糖尿病）的基础。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of this study is that glucose output by the liver increases with advancing age secondary to hepatic insulin resistance, independent of body weight or level of physical activity, thus leading to a predisposition of edlderly individuals to develop diabetes mellitus or impaired glucose tolerance. The aims of this study are: 1) to quantify hepatic glucose output under fasting conditions in both younger and older humans in order to understand the changes in glucose homeostasis associated with aging. 2) to determine the substrate sources for glucose synthesis in the liver and correlate this data with hepatic glucose production as a means of detecting the alterations in intermediary metabolism that may underlie metabolic diseases, such as diabetes mellitus, that are associated with advancing age.