RENAL DOPAMINERGIC PHARMACOGENOMICS

肾多巴胺能药物基因组学

• 批准号: 7374188
• 负责人: ROBERT J PARMER
• 金额: $ 0.05万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374188
• 关键词: essential hypertension; family genetics; genetics; hypertension; kidney; phenotype

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Establish uniform subsets of hypertensives whose hereditary pattern and pathogenesis can then be elucidated. These phenotypes are evaluated in pedigrees with multi-generational essential hypertension, in an attempt to define their mode of inheritance, and ultimately to undertake genetic likage and association analyses. The goal is to discover loci predisposing to these disturbed phenotypes in hypertension as well as to hypertension itself. This protocol focuses on phenotypes related to the renal dopaminergic system.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。建立统一的高血压子集，其遗传模式和发病机理可以阐明。这些表型在具有多代基本高血压的血统中进行评估，以定义其遗传方式，并最终进行遗传喜欢和关联分析。目的是发现高血压和高血压本身中这些干扰表型的基因座。该方案侧重于与肾脏多巴胺能系统有关的表型。