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Protein-protein interactions involving Munc18 in regulated exocytosis

Munc18 参与调节胞吐作用的蛋白质-蛋白质相互作用

基本信息

批准号：
BB/E006477/1
负责人：
Robert Burgoyne
金额：
$ 45.64万
依托单位：
University of Liverpool
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2007
资助国家：
英国
起止时间：
2007 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FE006477%2F1
关键词：
Protein protein interactions involving Munc18

项目摘要

Neurons, endocrine and many other cell types communicate with one another and other tissues in a co-ordinated manner by the tightly regulated release of transmitters and signalling molecules. Transmitters are packaged into small lipid vesicles which have to fuse with the cell membrane to release their contents only at the appropriate time and place. Most of the individual parts of the machinery inside the cell that allows this to occur have been discovered over the past ten years but we still have a very limited understanding of how the process works and how it is regulated. Changes in the functioning of the machinery for release are believed to contribute to learning and memory and affect behaviour. We aim to investigate in detail one essential component of the machinery, Munc18-1, by making specific modifications to its structure. This will allow us to learn how its interactions with other components contribute to its function in the various steps leading to transmitter release.

神经元、内分泌和许多其他类型的细胞通过严格调节的信号传递和信号分子的释放，以协调的方式与彼此和其他组织进行交流。递质被包装成小的脂质囊泡，这些脂质囊泡必须与细胞膜融合，才能在适当的时间和地点释放它们的内容物。在过去的十年里，我们已经发现了细胞内允许这种情况发生的机器的大多数单独部分，但我们对这个过程是如何工作的以及它是如何被调节的，了解仍然非常有限。释放机制的功能变化被认为有助于学习和记忆，并影响行为。我们的目标是通过对其结构进行具体修改来详细研究机械的一个重要组成部分Munc18-1。这将使我们能够了解其与其他组件的相互作用如何有助于其在导致发射器释放的各个步骤中的功能。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis.

DOI：
10.1371/journal.pone.0017999
发表时间：
2011-03-21
期刊：
PloS one
影响因子：
3.7
作者：
Graham ME;Prescott GR;Johnson JR;Jones M;Walmesley A;Haynes LP;Morgan A;Burgoyne RD;Barclay JW
通讯作者：
Barclay JW

Presynaptic targets for acute ethanol sensitivity