HEIRS

继承人

• 批准号: 7378662
• 负责人: Victor R Gordeuk
• 金额: $ 4.91万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-15 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378662
• 关键词: ferritin; iron poisoning; serum; transferrin

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the project is to determine the prevalence of primary iron overload in the African-American and Hispanic population of the Washington, D.C. area as part of a 5-year nationwide iron overload screening program b the National Institutes of Health. The primary hypothesis of the study is that non-HFE primary iron overload exists in the African American population. Year 1 will be devoted to planning, protocol development and pilot testing. In Years 2 and 3, an intial screening program, by determining the transferrin saturation and serum ferritin concentration in 20,000 subjects, will be conducted. Approximately 16,000 African American and 4,000 Hispanic patients will be screened at primary care facilities of Howard University Hospital and other institutions. Subjects with transferrin saturation and/or serum ferritin concentration above the 97.5 percentile (projected to be about 4.9% of the total or 980 subjects) will be followed up with a repeat determination of transferrin saturation and serum ferritin concentration. Subjects with confirmed elevations (projected to be about 20% of the subjects having repeat determinations or about 198 individuals) will undergo comprehensive clinical examinations during Years 2, 3 and 4. It is projected that primary iron overload will be found in about one-half (100) of the subjects undergoing comprehensive examination, and family studies will be performed on approximately 400 relatives of these subjects during Years 3 and 4. Subjects with primary iron overload will be followed during Years 2 to 5 of the study, with regards to morbidity and mortality. Assessments of Ethical, Legal and Social Issues (ELSI) will be done throughout the research program.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该项目的目的是确定华盛顿，华盛顿特区地区非洲裔美国人和西班牙裔人群中原发性铁过载的患病率，作为美国国立卫生研究院（National Institutes of Health）5年全国性铁过载筛查项目B的一部分。该研究的主要假设是非HFE原发性铁过载存在于非裔美国人人群中。第一年将专门用于规划、方案制定和试点测试。在第2年和第3年，将通过测定20，000名受试者的转铁蛋白饱和度和血清铁蛋白浓度来进行初步筛查计划。大约16,000名非洲裔美国人和4,000名西班牙裔患者将在霍华德大学医院和其他机构的初级保健设施接受筛查。对转铁蛋白饱和度和/或血清铁蛋白浓度高于97.5百分位数的受试者（预计约占980例受试者总数的4.9%）进行随访，重复测定转铁蛋白饱和度和血清铁蛋白浓度。确认升高的受试者（预计约占重复测定受试者的20%或约198例受试者）将在第2、3和4年接受全面临床检查。预计将在接受全面检查的约一半（100）受试者中发现原发性铁过载，并将在第3年和第4年期间对这些受试者的约400名亲属进行家族研究。在研究的第2年至第5年期间，将对原发性铁超负荷受试者的发病率和死亡率进行随访。伦理、法律的和社会问题评估（ELSI）将在整个研究计划中进行。