PILOT STUDY FOR THE TRANSLATING RESEARCH INTO THE PREVENTION OF DIABETES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项试点研究的总体目标是证明拟议的筛选、招募、干预和评估方法的可行性，该方法于2004年2月1日作为新申请提交给NIDDK。TRIP DM Trail是一项多学科转化研究，致力于将糖尿病预防项目的成果转化为实践。我们计划招募超重和肥胖的糖尿病前期成年人作为参与者，随机分配到一个强化的、以群体为基础的生活方式干预的双臂试验中，与常规护理治疗条件相比，有大量的外行健康咨询师参与，包括与注册营养师的单次会议，以获得简短的建议和有关社区资源的信息。主要结果是体内平衡模型测量的胰岛素抵抗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this pilot study is to demonstrate the feasibility of the proposed methods to screening, recruitment, intervention and assessment for the TRIP DM Trial submitted to the NIDDK as a new application on February 1, 2004. The TRIP DM Trail is a multidisciplinary translational study focused on translating the results of the Diabetes Prevention Program into practice. We plan to recruit, as participants, overweight and obese adults with pre-diabetes for randomization into a two-armed trail of an intensive, group-based lifestyle intervention with significant lay health counselor involvement compared with a usual care treatment condition, consisting of a single session with a registered dietician for brief advice and information regarding community resources. The primary outcome is insulin resistance as measured by the homeostasis model.