BIOMEDICAL (BASIC)

Sprint计划的主要目标是：1.确定将SBP治疗到低于目前推荐的目标是否会减少心血管疾病；2.在第三阶段CKD亚组中，确定强化干预是否会减少心血管疾病和肾脏疾病的进展；3.确定两种治疗策略对生活质量的相对影响；4.比较两种治疗策略的相对成本效益；5.确定强化干预是否会降低与年龄相关的认知损害的发生率；6.在一个子集中确定强化干预是否会降低与年龄相关的认知损害的发生率($print~Mind)。第二个目标是对Sprint-Mind子研究中2800名参与者的子集进行MRI成像。第三个目标是每年对所有7500名Sprint参与者进行筛查，以诊断可能的痴呆症(Sprint-Mind)；以及7.进行DNA提取和分析，以调查相关途径基因、全基因组关联和测序，以确定由于BP控制的相对水平而导致高血压风险和相关事件差异的全部功能变异。Sprint-Mind亚研究的主要目标如下：1.认知功能：确定强化干预是否会降低 认知功能减退与可能痴呆的发生率；2.成像：确定强化干预是否会降低中枢神经系统结构性异常的发生率 与血管性痴呆症有关，以及总脑体积的下降速度；3.可能痴呆症的诊断：每年对所有7500名参与者进行可能痴呆症的筛查。这项提议的目标是创建一个临床网络，招募1700名短跑参与者。

The major objectives of the SPRINT initiative are to: 1. determine whether treating SBP to a lower goal than currently recommended wil reduce CVD; 2. determine, in the stage 3 CKD subgroup, whether the intensive intervention wil reduce CVD and reduce the progression of renal disease; 3. determine the relative impact of the 2 treatment strategies on quality of life; 4. compare the relative cost effectiveness of the 2 treatment strategies; 5. determine whether the intensive intervention wil reduce the rate of age-related cognitive impairment; 6. determine, in a subset, whether the intensive intervention wil reduce the rate of age-related cognitive impairment ($PRINT~MIND). A second objective is to perform MRI imaging on a subset of the 2,800 participants in the SPRINT-MIND substudy. A third objective is to screen all 7,500 SPRINT participants annually in order to diagnose probable dementia (SPRINT-MIND); and 7. perform DNA extraction and analysis for investigation of relevant pathway genes, genome-wide association, and sequencing in order to define the full spectrum of variants functionally responsible for differences in hypertension risk and related events due to relative levels of BP control. The major objectives of the SPRINT-MIND Substudy are as follows: 1. Cognitive functioning: To determine whether the intensive intervention wil reduce the incidence of cognitive decline and incidence of probable dementia; 2. Imaging: To determine whether the intensive intervention wil reduce the incidence of structural central nervous system abnormalities related to vascular dementia, and rate of decline in total brain volume; and 3. Diagnosis of probable dementia: To screen all 7,500 participants annually for probable dementia. The objective of this proposal is to create a clinical network to recruit 1,700 SPRINT participants.