IMPACT OF SMOKING ON PAIN SENSITIVITY: LIGHT AND HEAVY SMOKERS VS NORMAL

吸烟对疼痛敏感性的影响：轻度吸烟者和重度吸烟者与正常吸烟者

• 批准号: 7376710
• 负责人: MICHELLE A VINCLER
• 金额: $ 1.27万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-17 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376710
• 关键词: lighting; nicotine; pain; tobacco

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is a small study to provide preliminary data on the impact of nicotine on pain sensitivities and will be performed under funding from the NIH Pain Center at Wake Forest University Health Sciences. The focus of the Pain Center has been centered on how chronic neuropathic pain alters the efficacy of traditional and non-traditional analgesics. One of the laboratory projects in the Center, headed by Michelle Vincler, PhD, seeks to understand behavioral and underlying receptor alterations in acute and chronic pain sensitivity in the presence of chronic nicotine. This clinical study attempts to translate strong behavioral observations in animals into humans. The goal of this study is to compare baseline responses to experimental pain testing across a range of nicotine exposure: no nicotine exposure (non-smokers), low level nicotine exposure (10-20 cigarettes per day), and high nicotine exposure (more than 40 cigarettes per day).

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项研究是一项小型研究，旨在提供有关尼古丁对疼痛敏感性影响的初步数据，并将在Wake Forest University Health Sciences的NIH疼痛中心的资金下进行。疼痛中心的重点集中在慢性神经性疼痛如何改变传统和非传统镇痛药的功效。 由Michelle Vincler博士领导的中心的一个实验室项目试图在存在慢性尼古丁的情况下了解急性和慢性疼痛敏感性的行为和潜在的受体改变。这项临床研究试图将动物的强烈行为观察转化为人类。这项研究的目的是比较一系列尼古丁暴露的实验疼痛测试的基线反应：没有尼古丁暴露（非吸烟者），低水平的尼古丁暴露（每天10-20支香烟）和高尼古丁的暴露（每天超过40支香烟）。