SOY AND ISOFLAVONES

大豆和异黄酮

• 批准号: 7377319
• 负责人: KAREN M PRESTWOOD
• 金额: $ 0.78万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377319
• 关键词: SOY; ISOFLAVONES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Osteoporosis is a disease that primarily affects older women in the United States. Epidemiological studies report decreased hip fracture incidence in Asian countries where the population ingests larger amounts of soy than is contained in the average US diet. Recent data suggest that soy intake is correlated with bone mineral density in Asian women. Soy foods are rich sources of isoflavones and these compounds may be responsible for the health benefits of soy. Although epidemiological and preliminary cross-sectional data suggest that soy may be beneficial to bone (1,2), few well-controlled clinical trials have been completed to adequately test this theory. Many women in the United States are demanding more 'natural' treatments for chronic diseases and a substantial proportion of women are already consuming more soy products or using isoflavone supplements. However, it is unclear if these practices are beneficial to postmenopausal women. We hypothesize that isoflavones and soy protein will have a beneficial effect on bone in older women compared to control protein. Further, we hypothesize that there will be an additional benefit to bone in women who receive soy protein plus isoflavones compared to control protein or soy protein alone. In order to test these hypotheses we propose an 1-year nutrition intervention study in women over age 65 years in which the main outcome measures will be biochemical markers of bone turnover, quality of life, bone mineral density.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。骨质疏松症是一种主要影响美国老年妇女的疾病。流行病学研究报告称，亚洲国家的髋部骨折发病率下降，这些国家的人口摄入的大豆量高于美国平均饮食中所含的大豆量。最近的数据表明，大豆摄入量与亚洲妇女的骨密度相关。大豆食品是丰富的大豆酮来源，这些化合物可能是大豆对健康有益的原因。尽管流行病学和初步的横断面数据表明大豆可能对骨骼有益（1，2），但很少有对照良好的临床试验能够充分验证这一理论。在美国，许多妇女要求更多的“自然”治疗慢性病，相当一部分妇女已经消费更多的豆制品或使用维生素补充剂。然而，目前尚不清楚这些做法是否对绝经后妇女有益。我们假设，与对照蛋白质相比，大豆酮和大豆蛋白将对老年妇女的骨骼产生有益影响。此外，我们假设，与对照蛋白或单独使用大豆蛋白相比，接受大豆蛋白加胆甾酮的女性对骨骼有额外的益处。为了检验这些假设，我们提出了一个为期1年的营养干预研究，在65岁以上的妇女，其中的主要结果措施将是骨转换，生活质量，骨密度的生化标志物。