DETERMINE VASCULAR RESISTANCE IN ARM DURING LBNP & FOREARM NEGATIVE PRESSURE

LBNP 期间确定手臂血管阻力

• 批准号: 7378454
• 负责人: Virginia Imadojemu
• 金额: $ 0.17万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378454
• 关键词: DETERMINE; VASCULAR; RESISTANCE; ARM; DURING

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a pilot study designed to determine the contribution of myogenic tone vs. sympathetic nervous system influences on vascular tone in skeletal muscle vascular beds. Ten healthy subjects ages 18 to 35 will be recruited to undergo procedures to determine vascular resistance in both arms during lower body negative pressure and localized negative pressure in one arm. The hypothesis to be tested is that vascular resistance will be higher in the arm under the influence of both myogenic (negative arm pressure) and sympathetic activity (lower body negative pressure) than the arm under sympathetic influence alone (no negative pressure). Subjects will have their arm and legs subjected to negative pressure according to established methods. Heart rate and blood pressure will be monitored by a finger cuff. Brachial artery flow and diameter will be assessed using a Doppler probe and intravenous catheters will be placed in each arm to monitor norepinephrine levels.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是一项初步研究，旨在确定肌原性张力与交感神经系统对骨骼肌血管床血管张力的影响。将招募10名年龄在18至35岁之间的健康受试者，进行手术，以确定下体负压和单臂局部负压时双臂的血管阻力。待验证的假设是，在肌源性（臂负压）和交感神经活动（下体负压）的影响下，臂上的血管阻力比单独受交感神经影响（无负压）的臂上的血管阻力要高。受试者将按照既定方法对手臂和腿部进行负压。心率和血压将通过手指袖带监测。使用多普勒探头评估肱动脉流量和直径，并在每只手臂上放置静脉导管以监测去甲肾上腺素水平。