DISCOVERY AND ASSESSMENT OF GENETIC AND ENVIRONMENT

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Host genetic, acquired factors and environmental influences affect the development, severity, progression, and outcome of many chronic diseases, including hepato-biliary-pancreatic diseases. To facilitate the discovery of new genetic factors that influence development or progression of chronic diseases, we need to develop tissue and DNA banks and correlate results of polymorphisms and mutational analyses (genotypes) with patient and clinical characteristics (phenotypes). To provide the necessary databases for such studies, we need to build-up clinical databases and tissue and DNA banks. This project is designed to accomplish this for patients with hepato-biliary diseases seen at UConn who will be undergoing liver biopsies for reasons unrelated to this study. We expect the database and specimen repository thus developed will allow us to perform important and informative new analyses, and will form the basis for new grant and contract applications in the future. It will serve as a paradigm for other studies in other diseases and disorders. The potential is great for studies of the kind. We need support from the GCRC cores in order to get these initiatives off to a successful start.