HFE MUTATIONS AND COLONIC ACF FORMATION AND PROGRESSION

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are proposing a study of HFE mutations, iron intake, and number and severity of aberrant crypt foci (ACF) in 800 screening colonscopy patients from the practice of Dr. Joel Levine. For this October 1 deadline to NIH, we hope to provide preliminary data on the HFE genotypes of the approximately 35 patients already archived in the Human ACF Repository maintained by Dan Rosenberg's laboratory at UConn Health Center. The GCRC now routinely conducts genotyping for HFE mutations. The ~40 subjects in the ACF Repository currently are half women and all caucasion. The HFE polymorphic variants to be studied are extremeely uncommon outside of the Euro-American population. These variants are most common in persons of Celtic origin. Therefore, the grant prposal will be restricted to Euro-Americans.