4th International Workshop on the Mast Cell & Basophil

描述：(申请人提供)肥大细胞在慢性阻塞性肺疾病中起核心作用 过敏、哮喘、癌症和皮肤纤维化，以及细菌和 蠕虫感染。最近的研究也表明这些效应细胞 HIV-1感染和多发性硬化症。第四届国际研讨会 肥大细胞激活和发育过程中的信号转导 嗜碱者将是一场紧张的科学会议，重点是最新的基本 对肥大细胞及其相关细胞嗜碱粒细胞的研究。这个 讲习班的具体目标是(1)介绍与以下方面有关的最新进展 调节细胞生长、分化和生长的因素和机制 肥大细胞和嗜碱性粒细胞的功能，(2)探讨新技术 直接影响肥大细胞和嗜碱性粒细胞研究的进展，以及(3) 将基础科学发现整合到治疗潜力的框架中 以及治疗过敏性炎症等疾病，这些疾病是由 一部分是由这些粒细胞造成的。研讨会的形式将包括七个 座谈会、两次海报会议和三次主旨演讲。威廉·保罗博士， 约瑟夫·施莱辛格和鲁本·西拉加尼安将作主旨演讲。 在七个研讨会上将有44个演讲。所有演讲者都是 肥大细胞和/或嗜碱性粒细胞特定方面的主要专家。仅限 尖端研究将在研讨会上展示。此外，一个重点是 将放在使用分子方法来解决特定方面 肥大细胞和嗜碱性细胞的发育和功能。我将重点关注研讨会 肥大细胞和嗜碱性粒细胞的发育。第二次和第三次专题讨论会的重点是 IgE/抗原介导的肥大细胞活化的早期和晚期事件 分别是嗜碱性粒细胞。第四次专题讨论会将集中讨论 胞吐。第五届会议将聚焦于非IgE介导的肥大细胞激活 和嗜碱性细胞，以及那些抑制激活的表面受体 回应。第六次专题讨论会将集中讨论一些从 激活的肥大细胞和嗜碱性粒细胞。最后，第七次研讨会将集中讨论 肥大细胞与其他细胞类型的双边相互作用。最新数据 与肥大细胞和/或嗜碱性粒细胞在多发性硬化症和 艾滋病毒-1感染问题也将在第七次专题讨论会上提出。

DESCRIPTION: (provided by applicant) Mast cells play a central role in chronic allergies, asthma, cancer, and skin fibrosis, as well as in bacteria and helminth infections. Recent studies also have implicated these effecter cells in HIV-1 infections and multiple sclerosis. The fourth International Workshop on Signal Transduction in the Activation and Development of Mast Cells and Basophils will be an intense scientific meeting focusing on the latest basic research earned on the mast cell and its related cell the basophil. The specific goals of the Workshop are (1) to present recent advances relating to the factors and mechanisms that regulate the growth, differentiation, and function of mast cells and basophils, (2) to discuss new technological advances that directly impact studies on mast cells and basophils, and (3) to integrate the basic science findings in the framework of therapeutic potential and treatment of diseases such as allergic inflammation which are mediated, in part, by these granulocytes. The Workshop's format will include seven Symposia, two Poster Sessions, and three Keynote Lectures. Drs. William Paul, Joseph Schlessinger, and Reuben Siraganian will give the Keynote Lectures. There will be 44 presentations in the seven Symposia. All presenters are leading authorities on specific aspects of the mast cell and/or basophil. Only cutting edge research will be presented at the Workshop. Moreover, an emphasis will be placed on the use of molecular approaches to address specific aspects of mast cell and basophil development and function. Symposia I will focus on the development of mast cells and basophils. Symposia II and III focus on early and late events in IgE/antigen-mediated activation of mast cells and basophils, respectively. Symposia IV will focus on the mechanisms of exocytosis. Symposia V will focus on non-IgE mediated activation of mast cells and basophils, as well as on those surface receptors that dampen activation responses. Symposia VI will focus on some of the mediators released from activated mast cells and basophils. Finally, Symposia VII will focus on the bilateral interactions of mast cells with other cell types. Recent data relating to the role of mast cells and/or basophils in multiple sclerosis and HIV-1 infection also will be presented in Symposia VII.