COLLAGENASE IN THE TREATMENT OF DUPUYTREN'S DISEASE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A Phase II random, placebo double blind trial of injectable collagenase is being studied as a non-operative treatment for Dupuytren's disease, a fixed flexion contracture deformity of the hand. This therapy may obviate the need for surgical fascioectomy for Dupuytren's disease.