GENETIC EPIDEMIOLOGY OF ENERGY METABOLISM

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to better understand how genes may influence resting energy expenditure in 12 ¿ 16 year old African American girls which may contribute to the development of obesity during adolescence. There are two parts to the study. Initially, we will buccal screen 1000 girls for genotyping. Those that are a match the specific genes we are interested in, will be asked to come for an overnight visit at Cincinnati Children's Hospital Medical Center's General Clinical Research Center. At the overnight visit, the subject will have measurements of body composition such as height, weight and skinfolds. The subject will also have a DXA scan, blood draw, and a Resting Energy test.