HEPATITIS C PREVALENCE IN PERINATALLY INFECTED HIV-INFECTED CHILDREN

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a prevalence study of Hepatitis C Virus (HCV) infection. 600 perinatally-infected HIV-infected children greater than or equal to one year to less than 21 years of age who are enrolled in PACTG 219C will be enrolled in this substudy. A single blood draw for HCV antibody (EnzymeImmunoassay-EIA) testing and HCV RNA (Polymerase Chain Reaction-PCR) testing. One visit for HCV negative subjects; two visits for subjects with positive HCV test results; two or three visits for subjects discordant HCV test results. The primary objective of this study is to determine the prevalence of Hepatitis C in a randomly selected subset of perinatally-infected HIV-positive children enrolled in PACTG 219C. Other objectives are to perform descriptive analyses of possible co-factors in the perinatal transmission of Hepatitis C virus; to perform descriptive analyses of clinical symptoms and liver function tests in subjects found to be HCV-infected; to compare the performance of HCV antibody testing (EIA) and HCV RNA PCR testing in children; and to achieve samples for Hepatitis C virus testing at a future date.