ASSOCIATION BETWEEN PERIODIC LIMB MOVEMENT DISORDERS AND FERRITIN LEVEL IN CHILD

儿童周期性肢体运动障碍与铁蛋白水平之间的关联

• 批准号: 7376269
• 负责人: NARONG SIMAKAJORNBOON
• 金额: $ 0.02万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376269
• 关键词: ASSOCIATION; BETWEEN; PERIODIC; LIMB; MOVEMENT

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Periodic Limb Movement Disorder refers to the condition which repetitive movements of legs and arms occurs during sleep. There is a clear tendency for the prevalence to increase with age. This disorder can occur in young children. This condition disturbs sleep and leads to the inability to sleep, excessive daytime sleepiness or hyperactivity in children. There is no FDA approved medication for PLMD in children. The current medications that are commonly used by pediatric sleep specialists and are recommended by the American Academy of Sleep Medicine for treatment of PLMD in children include Clonazepam, Dopamine receptor agonists and Levadopa. This study is aimed to evaluate the relationship between PLMD and ferritin level in children. In addition, children who have low ferritin level (<50ng/ml) will receive treatment with ferrous sulfate. The response of treatment will be monitored by improvement in the symptoms and actigraphy. The actigraphy is a small watch that children wear on the wrist during sleep and it records the frequency of arm movements during sleep. Our aim is to find if simple medication like iron can be used to treat children with periodic limb movement disorder.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。周期性肢体运动障碍是指在睡眠期间发生腿部和手臂重复运动的情况。有一个明显的趋势，即流行率随着年龄的增长而增加。这种疾病可以发生在幼儿身上。这种情况会干扰睡眠，导致无法入睡，白天过度嗜睡或儿童多动症。目前还没有FDA批准的治疗儿童PLMD的药物。目前儿科睡眠专家常用的药物以及美国睡眠医学学会推荐的用于治疗儿童PLMD的药物包括氯硝西泮、多巴胺受体激动剂和左旋多巴。本研究旨在探讨儿童PLMD与铁蛋白水平的关系。此外，铁蛋白水平低（<50 ng/ml）的儿童将接受硫酸亚铁治疗。将通过症状改善和体动记录监测治疗反应。腕动记录仪是一个小手表，孩子们在睡眠时戴在手腕上，它记录了睡眠时手臂运动的频率。我们的目的是发现是否像铁这样的简单药物可以用来治疗患有周期性肢体运动障碍的儿童。