PHASE III TRIAL OF CONCURRENT RADIATION AND CHEMOTHERAPY FOR HEAD/NECK CANCER

头颈癌同步放疗和化疗的 III 期试验

• 批准号: 7376289
• 负责人: Jill Gilbert
• 金额: $ 0.54万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376289
• 关键词: PHASE; III; TRIAL; CONCURRENT; RADIATION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The treatment of advanced head and neck squamous cell carcinomas (HNSCC) has been the subject of intensive investigation during the last two decades. Up to a few years ago, surgical resection, often followed by adjuvant radiotherapy, was the standard of care in most cases despite the resulting cosmetic and functional impairment affecting the quality of life (QOL). Results of conventionally fractionated radiotherapy as a single modality for patients with resectable and unresctable advanced HNSCC are rather poor in terms of local control and survival. Therefore, new fractionation regimens and the combination of radiation and chemotherapy have been studied to improve non-surgical treatment results of advanced head and neck cancers. The main purpose of this study is to compare the standard treatment for advanced head and neck cancer with another method of giving radiation treatments. The researchers of this study will be looking at the effects of the regimens on subjects and their quality of life. Biologic markers will also be studied to assist in predicting and treating head and neck cancer patients in the future.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。在过去的二十年里，晚期头颈部鳞状细胞癌(HNSCC)的治疗一直是深入研究的主题。直到几年前，手术切除，通常在辅助放射治疗之后，是大多数病例的标准护理，尽管由此导致的美容和功能损害影响了生活质量(QOL)。传统的分割放射治疗对于可切除和不可切除的晚期HNSCC患者来说，在局部控制和生存方面的结果是相当差的。因此，为了提高晚期头颈癌的非手术治疗效果，人们研究了新的分割方案和放化疗相结合的方法。这项研究的主要目的是比较晚期头颈癌的标准治疗方法和另一种给予放射治疗的方法。这项研究的研究人员将观察这些养生法对受试者及其生活质量的影响。生物标志物也将被研究，以帮助预测和治疗未来的头颈癌患者。