CARDIOVASCULAR LINKAGE BETWEEN ENDOTHELIAL FUNCTION & AIR POLLUTION

内皮功能之间的心血管联系

• 批准号: 7376546
• 负责人: Robert Daniel Brook
• 金额: $ 2.1万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376546
• 关键词: air pollution; blood; blood pressure; blood vessels

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Air pollution increases the risk for heart and vascular disease. This study is designed to improve our understanding of how air pollution effects blood vessels. Healthy, non-smoking adults, ages 18-50, of any gender, race or ethnicity, will be recruited to evaluate the impact of pollution on blood vessel function, blood pressure, and blood labs. Each subject will have their blood vessel function tested by an ultrasound and blood drawn before and immediately after breathing air that contains pollution concentrated from the natural atmosphere for 2 hours. The amount of pollution in the air is similar to that may be found in a busy city. In past studies subjects could not tell the difference between the "dirty" air and the clean air. A blood pressure monitoring cuff will be worn the day prior to and after the exposure. One hour prior to each exposure subjects will receive a pre-treatment of either a sugar pill (placebo), Vitamin C 2 g, or a blood pressure medication (Bosentan 500 mg). Patients will return the day after the exposure for a blood draw and a blood vessel function test. There will be a total of 3 study visits. During each visit patients will be exposed to the same air pollution, but will receive a different pre-treatment medication in random order.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。空气污染会增加心脏和血管疾病的风险。这项研究旨在提高我们对空气污染如何影响血管的了解。将招募18-50岁的健康、不吸烟的成年人，不分性别、种族或民族，以评估污染对血管功能、血压和血液实验室的影响。每名受试者将通过超声波测试他们的血管功能，并在呼吸含有天然大气中浓缩的污染物的空气2小时之前和之后立即抽血。空气中的污染程度与在一个忙碌的城市中可能发现的污染程度相似。在过去的研究中，受试者无法区分“脏”空气和清洁空气。暴露前一天和暴露后一天将佩戴血压监测袖带。每次暴露前1小时，受试者将接受糖丸（安慰剂）、维生素C 2 g或血压药物（波生坦500 mg）的预治疗。患者将在暴露后第二天返回进行抽血和血管功能测试。总共将进行3次研究访视。在每次访问期间，患者将暴露于相同的空气污染，但将以随机顺序接受不同的治疗前药物。