VASCULAR TISSUE ANGIOTENSINII & ENDOTHELIAL DYSFUNCTION IN UNCOMPLICATED OBESITY

血管组织血管紧张素II

• 批准号: 7376511
• 负责人: Robert Daniel Brook
• 金额: $ 0.31万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376511
• 关键词: angiotensinogen; blood vessels; obesity; tissues

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Excess weight around the waist is associated with poor blood vessel function and increased cardiovascular risk. However, the mechanism is unclear. A substance in the body called angiotensinogen II may play a role. By blocking the production of angiotensinogen II with a medication called valsartan, blood vessel function may be improved in people ages 18-50 who have excess abdominal girth and are otherwise healthy. Brachial artery flow-mediated dilatation, forearm plethysmography, cutaneous laser doppler blood flow and computerized arterial pulse waveform analysis will be used to study the responses of the blood vessels. Subjects will be randomly given both valsartan and placebo at different times to determine if candesartan improves blood vessel function.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。腰围超重与血管功能差和心血管风险增加有关。然而，其机制尚不清楚。体内一种叫做血管紧张素原II的物质可能起作用。通过一种叫做缬沙坦的药物阻断血管紧张素原II的产生，18-50岁的腹部腰围过大但其他方面健康的人的血管功能可能会得到改善。肱动脉血流介导的扩张、前臂体积描记、皮肤激光多普勒血流和计算机动脉脉搏波形分析将用于研究血管的反应。受试者将在不同时间随机给予缬沙坦和安慰剂，以确定坎地沙坦是否能改善血管功能。