VASCULAR TISSUE ANGIOTENSINII & ENDOTHELIAL DYSFUNCTION IN UNCOMPLICATED OBESITY
血管组织血管紧张素II
基本信息
- 批准号:7376511
- 负责人:
- 金额:$ 0.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-04-05 至 2007-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Excess weight around the waist is associated with poor blood vessel function and increased cardiovascular risk. However, the mechanism is unclear. A substance in the body called angiotensinogen II may play a role. By blocking the production of angiotensinogen II with a medication called valsartan, blood vessel function may be improved in people ages 18-50 who have excess abdominal girth and are otherwise healthy. Brachial artery flow-mediated dilatation, forearm plethysmography, cutaneous laser doppler blood flow and computerized arterial pulse waveform analysis will be used to study the responses of the blood vessels. Subjects will be randomly given both valsartan and placebo at different times to determine if candesartan improves blood vessel function.
这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金,因此可能会出现在其他CRISE条目中。列出的机构是针对中心的,而不一定是针对调查员的机构。腰围超重与血管功能不佳和心血管风险增加有关。然而,其机制尚不清楚。体内一种名为血管紧张素原II的物质可能起到了一定作用。通过使用一种名为valsartan的药物阻断血管紧张素原II的产生,18-50岁腹围超标但其他方面健康的人的血管功能可能会得到改善。采用肱动脉血流介导的扩张、前臂容积图、皮肤激光多普勒血流和计算机动脉脉搏波分析来研究血管的反应。受试者将在不同的时间随机服用valsartan和安慰剂,以确定坎地沙坦是否改善血管功能。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert Daniel Brook其他文献
Robert Daniel Brook的其他文献
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{{ truncateString('Robert Daniel Brook', 18)}}的其他基金
Reducing Particulate Matter-Associated Cardiovascular Health Effects for Seniors
减少颗粒物对老年人心血管健康的影响
- 批准号:
10207776 - 财政年份:2014
- 资助金额:
$ 0.31万 - 项目类别:
Reducing Particulate Matter-Associated Cardiovascular Health Effects for Seniors
减少颗粒物对老年人心血管健康的影响
- 批准号:
10427306 - 财政年份:2014
- 资助金额:
$ 0.31万 - 项目类别:
Reducing Particulate Matter-Associated Cardiovascular Health Effects for Seniors
减少颗粒物对老年人心血管健康的影响
- 批准号:
10011861 - 财政年份:2014
- 资助金额:
$ 0.31万 - 项目类别:
COUNTERACT Supplement--ASPIRE: Air Pollution: Strategies for Personalized Intervention to Reduce Exposure
COUNTERACT 补充--ASPIRE:空气污染:减少接触的个性化干预策略
- 批准号:
10218398 - 财政年份:2011
- 资助金额:
$ 0.31万 - 项目类别:
ASPIRE: Air Pollution: Strategies for Personalized Intervention to Reduce Exposure
ASPIRE:空气污染:减少接触的个性化干预策略
- 批准号:
9754146 - 财政年份:2011
- 资助金额:
$ 0.31万 - 项目类别:
CARDIOVASCULAR LINKAGE BETWEEN ENDOTHELIAL FUNCTION & AIR POLLUTION
内皮功能之间的心血管联系
- 批准号:
7603730 - 财政年份:2007
- 资助金额:
$ 0.31万 - 项目类别:
CARDIOVASCULAR LINKAGE BETWEEN ENDOTHELIAL FUNCTION & AIR POLLUTION
内皮功能之间的心血管联系
- 批准号:
7376546 - 财政年份:2006
- 资助金额:
$ 0.31万 - 项目类别:
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