COGNITIVE & PHARMACOLOGICAL MODULATION OF HUMAN NEUROENDOCRINE STRESS AXIS-CRH

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这个研究项目将有助于我们了解大脑如何调节我们对压力反应所涉及的激素和行为。我们还将探讨心理因素的作用，这些因素可能会影响垂体和肾上腺释放压力激素。参与者将是一组健康的人，他们没有任何焦虑，抑郁或压力相关疾病的特殊问题。将有大约30名年龄在18至45岁之间的受试者，他们在医学上是健康的，没有服用药物或药物。受试者将在两个下午入住密歇根大学医院的综合临床研究中心。他们将在手臂的静脉中放置静脉输液管约5小时。我们将通过这条线抽取血液样本，并使用它给他们一种称为促肾上腺皮质激素释放激素（CRH）的激素或安慰剂（非活性物质）。CRH是一种大脑化学物质，通过直接刺激脑垂体释放另一种激素（促肾上腺皮质激素），对我们感兴趣的应激激素的释放提供主要控制，脑垂体是位于大脑底部的重要腺体。我们将测量促肾上腺皮质激素和皮质醇，这两者都是人们在试图科普挑战或压力时释放的。我们将使用不同类型的指令来研究思想和感受如何影响这些激素的释放。受试者接受的指导将随机确定。这项研究可能有助于我们更好地了解心理因素在人类应激反应系统中的作用。我们希望这项工作将有助于制定更好的压力管理方法。我们还希望它能帮助我们开发出一些模型，用于研究不同精神疾病中的人类应激反应系统，或许还能帮助我们寻找其中一些疾病的原因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research project will contribute to our understanding of how the brain regulates the hormones and behaviors involved in our responses to stress. We will also be exploring the role of psychological factors that might affect the release of stress hormones from the pituitary and adrenal glands. Participants will be a group of healthy people who do not have any particular problems with anxiety, depression, or stress-related disorders. There will be about 30 subjects between 18 and 45 years of age, who are medically healthy and are not taking medication or drugs. Subjects will be admitted on two afternoons to the General Clinical Research Center at the University of Michigan Hospital. They will have an intravenous line in place in a vein in their arm for about 5 hours. We will draw blood samples through this line and will also use it to give them either a dose of a hormone called corticotropin-releasing hormone (CRH) or a placebo (inactive substance). CRH is a brain chemical that provides primary control over the release of the stress hormones we are interested in, by directly stimulating the release of another hormone (adrenocorticotropin) from the pituitary gland, which is an important gland located at the base of the brain. We will be measuring both adrenocorticotropin and cortisol, both of which are released by people when attempting to cope with a challenge or stressor. We will be using different types of instructions to also study how thoughts and feelings can affect release of these hormones. Which instructions subjects receive will be determined randomly. The study may help us better understand the role of psychological factors in human stress response systems. We hope this work will contribute to the development of improved approaches to the management of stress. We also hope that it will help us to develop models that will be useful in studying the human stress response system in different psychiatric disorders and perhaps help us search for the causes of some of these disorders.