COGNITIVE & PHARMACOLOGICAL MODULATION OF HUMAN NEUROENDOCRINE STRESS AXIS-CRH

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究项目将有助于我们理解大脑如何调节我们对压力的反应中涉及的荷尔蒙和行为。我们还将探索可能影响脑下垂体和肾上腺释放应激激素的心理因素的作用。参与者将是一群健康的人，他们没有任何特别的焦虑、抑郁或压力相关障碍问题。将有大约30名年龄在18岁到45岁之间的受试者，他们的身体健康，没有服用药物或药物。受试者将在两个下午进入密歇根大学医院的综合临床研究中心。他们将在手臂上的静脉中放置一条静脉导管，持续大约5个小时。我们将通过这条线抽取血液样本，并将使用它来给他们服用一种名为促肾上腺皮质激素释放激素(CRH)的激素或安慰剂(非活性物质)。CRH是一种大脑化学物质，通过直接刺激脑下垂体释放另一种激素(促肾上腺皮质激素)，对我们感兴趣的应激激素的释放提供主要控制。脑下垂体是位于大脑底部的一个重要腺体。我们将同时测量促肾上腺皮质激素和皮质醇，这两种激素都是在人们试图应对挑战或压力时释放的。我们将使用不同类型的指令来研究思想和感觉如何影响这些荷尔蒙的释放。受试者收到的指令将随机确定。这项研究可能有助于我们更好地理解心理因素在人类应激反应系统中的作用。我们希望这项工作将有助于制定更好的压力管理办法。我们还希望它能帮助我们开发模型，这些模型将有助于研究人类在不同精神障碍中的压力反应系统，或许还能帮助我们寻找其中一些精神障碍的原因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research project will contribute to our understanding of how the brain regulates the hormones and behaviors involved in our responses to stress. We will also be exploring the role of psychological factors that might affect the release of stress hormones from the pituitary and adrenal glands. Participants will be a group of healthy people who do not have any particular problems with anxiety, depression, or stress-related disorders. There will be about 30 subjects between 18 and 45 years of age, who are medically healthy and are not taking medication or drugs. Subjects will be admitted on two afternoons to the General Clinical Research Center at the University of Michigan Hospital. They will have an intravenous line in place in a vein in their arm for about 5 hours. We will draw blood samples through this line and will also use it to give them either a dose of a hormone called corticotropin-releasing hormone (CRH) or a placebo (inactive substance). CRH is a brain chemical that provides primary control over the release of the stress hormones we are interested in, by directly stimulating the release of another hormone (adrenocorticotropin) from the pituitary gland, which is an important gland located at the base of the brain. We will be measuring both adrenocorticotropin and cortisol, both of which are released by people when attempting to cope with a challenge or stressor. We will be using different types of instructions to also study how thoughts and feelings can affect release of these hormones. Which instructions subjects receive will be determined randomly. The study may help us better understand the role of psychological factors in human stress response systems. We hope this work will contribute to the development of improved approaches to the management of stress. We also hope that it will help us to develop models that will be useful in studying the human stress response system in different psychiatric disorders and perhaps help us search for the causes of some of these disorders.'