OUTCOME OF PTS TREATED IN EMERGENCY DEPARTMENT AFTER MOTOR VEHICLE COLLISION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。个人往往在创伤性事件发生后出现慢性问题。此前的研究表明，轻微机动车碰撞(MVC)后，多达三分之一的患者会出现心理后遗症，包括创伤后应激障碍、抑郁症和焦虑症。此外，10%-30%的患者出现慢性区域性疼痛(颈部或背部疼痛)。尽管它们经常发生，但这些疾病的危险因素和疾病发展过程仍然知之甚少。这项拟议的研究试图通过对MVC轻微创伤后患者预后的全面检查，在这些领域获得重要的新理解。将从当地两个急救部门招募600名E18岁或以上的妇女。同意ED研究的患者将接受30-45分钟的ED评估，包括与车祸相关的、心理社会和生物因素，并在1个月和6个月时完成邮件/电话随访。那些拒绝参与的人将被问及是否愿意在6个月后接到1个后续电话，看看他们做得如何。完成ED评估方案的患者将被问及是否有兴趣收到关于在门诊进行的单独的、相关的后续研究的信息。同意的患者将在MVC后3-7天返回研究诊所，并将进行更详细的评估，包括更深入的心理社会和生物因素评估，以及疼痛和心理处理的功能磁共振评估。有症状的患者将在1个月、3个月和6个月时继续返回门诊进行进一步评估。最初来到研究诊所，但后来康复的患者将通过邮件/电话在1个月和/或6个月完成随访。从这项研究中获得的丰富信息将用于识别高危患者，了解疾病机制，并开发二级药物和/或行为干预措施，以预防创伤事件后的慢性疼痛和心理后遗症。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Individuals often develop chronic problems after traumatic events. Previous studies have shown that after minor motor vehicle collision (MVC), up to 1/3 of patients will develop psychological sequelae, including posttraumatic stress disorder, depression, and anxiety disorders. In addition, 10-30% of patients develop chronic regional pain (neck or back pain). Despite their common occurrence, the risk factors and processes of disease development for these disorders remain poorly understood. The proposed study seeks to gain important new understanding in these areas, through a comprehensive examination of patient outcomes after minor MVC trauma. 600 women e18 years of age or older will be recruited from 2 local emergency departments. Patients who consent to the ED study will undergo a 30-45 minute ED assessment of crash-related, psychosocial, and biological factors, and complete mail/telephone follow-up at 1 and 6 months. Those who decline participation will be asked if they would be willing to receive 1 follow-up phone call at 6 months to see how they are doing. Patients who complete the ED assessment protocol will be asked if they would be interested in receiving information regarding a separate, related follow-up study conducted in an outpatient clinic. Consenting patients will return to the research clinic 3-7 days after the MVC, and will have a more detailed evaluation, including a more in-depth evaluation of psychosocial and biological factors, and functional MRI assessment of pain and psychological processing. Patients who are symptomatic will continue to return to the outpatient clinic for further evaluations, at 1 month, 3 months, and 6 months. Patients who initially come to the research clinic, but subsequently recover, will complete follow-up at 1 month and/or 6 months via mail/telephone. The wealth of information gained from this study will be used to identify high risk patients, understand mechanisms of disease, and develop secondary pharmacologic and/or behavioral interventions to prevent chronic pain and psychological sequelae after traumatic events.