SLEEP DISORDERS AND IMMUNE RESPONSE TO THE FLU SHOT

睡眠障碍和流感疫苗的免疫反应

• 批准号: 7376650
• 负责人: Flavia B Consens
• 金额: $ 6.44万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376650
• 关键词: active immunization; antibody; antibody titering; immune response; immunization; influenza; sleep; sleep deprivation; sleep disorders

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will evaluate the effectiveness of influenza immunization on antibody responsiveness in subjects with normal self reported sleep habits and on those with sleep disorders. The general aim of this project is to determine whether sleep disorders negatively impact immune function. We will determine IgG antibody titers from normal sleepers and from subjects with disturbed sleep, including subjects with insomnia, circadian rhythm disorders (shift workers) and obstructive sleep apnea. Antibody titers will be determined from blood samples taken prior to vaccination and at 10 and 30 days after vaccination. Subjects will have a sleep study performed to confirm inclusion in the appropriate group, and keep logs of sleep and flu symptoms. The deleterious effects of sleep disorders on the immune system, and specifically antibody response to influenza vaccination, have been recently demonstrated in a partial sleep deprivation study, where sleep deprived healthy young adults had an antibody response to immunization of less than half the one of subjects with normal sleep. The impact on immune function of sleep deprivation or sleep disorders in the general population has not been evaluated.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究将评估流感疫苗对自我报告睡眠习惯正常的受试者和睡眠障碍受试者的抗体反应性的有效性。这个项目的总体目标是确定睡眠障碍是否会对免疫功能产生负面影响。我们将检测正常睡眠者和睡眠障碍者的免疫球蛋白抗体效价，包括失眠、昼夜节律紊乱(轮班工人)和阻塞性睡眠呼吸暂停患者。抗体滴度将从接种疫苗前以及接种后10天和30天采集的血液样本中检测。受试者将进行睡眠研究，以确认是否属于适当的小组，并记录睡眠和流感症状。睡眠障碍对免疫系统的有害影响，特别是对流感疫苗的抗体反应，最近在一项部分睡眠剥夺研究中得到了证明，在该研究中，睡眠不足的健康年轻人对免疫的抗体反应不到正常睡眠受试者的一半。睡眠剥夺或睡眠障碍对普通人群免疫功能的影响尚未得到评估。