ECG-GATED 16-SLICE CTCA: COMPARISON WITH CATHETER CORONARY ANGIOGRAPHY

心电门控 16 层 CTCA：与导管冠状动脉造影的比较

• 批准号: 7376562
• 负责人: SMITA S PATEL
• 金额: $ 1.53万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376562
• 关键词: aging; angiography; catheterization; coronary disorder; death; heart; heart catheterization; lead; pain; thorax

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Disease of the coronary arteries, which may ultimately lead to a heart attack, is the leading cause of death in the United States, accounting for 30% of all deaths in the United States in the year 2000 (NIH statistics). The state of Michigan has the 4th highest age-adjusted death rate for CAD in USA. Catheter coronary angiography is currently the best diagnostic tool available to detect blood flow problems in the major vessels of the heart, however, it is a invasive procedure with many associated risks. We would like to determine if CT Coronary Angiography using the newer faster 64-slice CT scanner (a CAT Scan of your heart and major arteries of the heart) is an accurate imaging modality for diagnosing coronary artery disease. This study hopes to show that by using new CT scanning techniques we will be able to diagnose heart conditions accurately, and more safely, than heart catheterization. Men and women 18 years of age or older who are scheduled to have a heart catheterization by their physician can participate in this study. We will enroll subjects both who have had or have not had a previous heart intervention such as angioplasty, stent placement or coronary artery bypass surgery. If CT coronary angiography proves to be a robust imaging tool, it may become useful both in patients with chest pain, and atypical chest pain, when it is difficult to know whether the pain in the chest is originating from the heart or not. Potential advantages of CT include decreased radiation dose vs cardiac catheterization and that a greater number of people with possible heart disease may opt for this non-invasive test. The test may also prove to be less expensive than cardiac catheterization. If CT is accurate for the diagnosis of coronary artery disease, it may be possible to use CT to screen asymptomatic individuals with a high risk factor profile for coronary artery disease; with the long term goal of reducing acute cardiac events and death from coronary artery disease.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。冠状动脉疾病，最终可能导致心脏病发作，是美国死亡的主要原因，占2000年美国所有死亡人数的30% （NIH统计）。密歇根州的CAD年龄调整死亡率在美国排名第四。导管冠状动脉造影是目前可用来检测心脏主要血管血流问题的最佳诊断工具，然而，它是一种具有许多相关风险的侵入性手术。我们想确定使用更新更快的64层CT扫描仪（心脏和心脏主要动脉的CAT扫描）的CT冠状动脉造影是否是诊断冠状动脉疾病的准确成像方式。这项研究希望表明，通过使用新的CT扫描技术，我们将能够比心导管更准确、更安全地诊断心脏病。年龄在18岁或以上的男性和女性，如果他们的医生安排了心导管插入术，都可以参加这项研究。我们将招募有过或没有做过心脏干预手术的受试者，如血管成形术、支架置入或冠状动脉搭桥手术。如果CT冠状动脉造影被证明是一种强大的成像工具，它可能对胸痛和非典型胸痛患者都有用，因为胸痛很难知道是否源于心脏。与心导管相比，CT的潜在优势包括降低辐射剂量，更多可能患有心脏病的人可能会选择这种非侵入性检查。这项检查也可能比心导管检查更便宜。如果CT对冠状动脉疾病的诊断是准确的，那么可以使用CT筛查具有冠状动脉疾病高风险因素的无症状个体；长期目标是减少急性心脏事件和冠状动脉疾病的死亡。