ECG-GATED 16-SLICE CTCA: COMPARISON WITH CATHETER CORONARY ANGIOGRAPHY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Disease of the coronary arteries, which may ultimately lead to a heart attack, is the leading cause of death in the United States, accounting for 30% of all deaths in the United States in the year 2000 (NIH statistics). The state of Michigan has the 4th highest age-adjusted death rate for CAD in USA. Catheter coronary angiography is currently the best diagnostic tool available to detect blood flow problems in the major vessels of the heart, however, it is a invasive procedure with many associated risks. We would like to determine if CT Coronary Angiography using the newer faster 64-slice CT scanner (a CAT Scan of your heart and major arteries of the heart) is an accurate imaging modality for diagnosing coronary artery disease. This study hopes to show that by using new CT scanning techniques we will be able to diagnose heart conditions accurately, and more safely, than heart catheterization. Men and women 18 years of age or older who are scheduled to have a heart catheterization by their physician can participate in this study. We will enroll subjects both who have had or have not had a previous heart intervention such as angioplasty, stent placement or coronary artery bypass surgery. If CT coronary angiography proves to be a robust imaging tool, it may become useful both in patients with chest pain, and atypical chest pain, when it is difficult to know whether the pain in the chest is originating from the heart or not. Potential advantages of CT include decreased radiation dose vs cardiac catheterization and that a greater number of people with possible heart disease may opt for this non-invasive test. The test may also prove to be less expensive than cardiac catheterization. If CT is accurate for the diagnosis of coronary artery disease, it may be possible to use CT to screen asymptomatic individuals with a high risk factor profile for coronary artery disease; with the long term goal of reducing acute cardiac events and death from coronary artery disease.'