OBSTRUCTIVE SLEEP APNEA AND IMPAIRED GLUCOSE REGULATION

阻塞性睡眠呼吸暂停和血糖调节受损

• 批准号: 7376573
• 负责人: Amanda C Peltier
• 金额: $ 1.07万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376573
• 关键词: blood; cardiovascular disorder risk; conditioning; glucose; learning; sleep; sleep apnea

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to learn whether obstructive sleep apnea (OSA), a condition in which breathing is affected during sleep, can cause abnormal blood sugar (glucose) processing, which could lead to diabetes, or pre-diabetic conditions. In addition, both OSA and diabetes are linked to autonomic dysfunction of the parasympathetic and sympathetic nervous system, which controls heart rate and blood pressure. It is unclear whether the autonomic dysfunction found in OSA is due to diabetic or pre-diabetic conditions, or whether it caused by OSA independently. OSA and diabetes are commonly found in overweight individuals and both can cause increased risk of heart disease and strokes. Autonomic dysfunction is thought to increase the risk of heart disease in both of these conditions. OSA is a treatable condition, utilizing nasal continuous positive airway pressure (CPAP), which blows air into the nose, overcoming the obstruction to airflow that occurs in OSA. During this study, subjects identified by their doctors as having symptoms of OSA and referred for a sleep study (polysomnogram or PSG) will be asked to participate in this study. Patients will undergo a PSG to determine whether they have OSA. The following morning, patients will be asked to undergo a glucose tolerance test (OGTT) in which blood is taken before and after drinking a sugary drink. Several tests of the autonomic system will be performed. Patients who are diagnosed with OSA will be brought back to the sleep lab to determine what kind of CPAP is needed for their treatment and given a prescription. After 6 months, patients will be asked to return for a second OGTT and repeat autonomic tests. By performing this study, we hope to learn whether patients with OSA have an increased prevalence of diabetes or pre-diabetic condition, characterize the autonomic dysfunction associated with these disorders, and determine whether nasal CPAP will improve glucose metabolism and/or autonomic function in people who do have abnormal processing of blood sugar.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项研究的目的是了解阻塞性睡眠呼吸暂停（OSA）是否会导致血糖（葡萄糖）处理异常，从而导致糖尿病或糖尿病前期疾病。阻塞性睡眠呼吸暂停是一种在睡眠中呼吸受到影响的疾病。此外，阻塞性睡眠呼吸暂停和糖尿病都与控制心率和血压的副交感神经系统的自主神经功能障碍有关。目前尚不清楚OSA中发现的自主神经功能障碍是由于糖尿病或糖尿病前期状况所致，还是由OSA独立引起的。睡眠呼吸暂停和糖尿病常见于超重人群，两者都会增加患心脏病和中风的风险。在这两种情况下，自主神经功能障碍被认为会增加患心脏病的风险。OSA是一种可治疗的疾病，利用鼻腔持续气道正压通气（CPAP），将空气吹入鼻腔，克服OSA中发生的气流阻塞。在本研究中，被医生确定为有OSA症状并被推荐进行睡眠研究（多导睡眠图或PSG）的受试者将被要求参加本研究。患者将接受PSG检查以确定是否患有阻塞性睡眠呼吸暂停。第二天早上，患者将被要求进行葡萄糖耐量试验（OGTT），在饮用含糖饮料之前和之后取血。将对自主神经系统进行几项测试。被诊断为阻塞性睡眠呼吸暂停的患者将被带回睡眠实验室，以确定他们的治疗需要哪种CPAP，并开出处方。6个月后，患者将被要求返回进行第二次OGTT并重复自主神经测试。通过这项研究，我们希望了解OSA患者是否有糖尿病或糖尿病前期的患病率增加，表征与这些疾病相关的自主神经功能障碍，并确定鼻腔CPAP是否会改善血糖处理异常的人的葡萄糖代谢和/或自主神经功能。