PILOT COLLABORATIVE PET IMAGING TRIAL

宠物成像协作试点试验

• 批准号: 7376584
• 负责人: JUDITH L HEIDEBRINK
• 金额: $ 0.77万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376584
• 关键词: Alzheimer' s disease; behavior; brain; brain imaging /visualization /scanning; cognition disorders; conditioning; counseling; dementia; depression; medical records; physicians; positron emission tomography; sex; social behavior disorders; thinking; university

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Frontotemporal dementia (FTD) is a brain disease that causes progressive worsening of behavior and thinking. Currently it is difficult to diagnose FTD accurately because symptoms overlap with other illnesses such as Alzheimer s disease (AD) and depression. It is important to be able to distinguish these conditions in order to provide the most appropriate counseling and treatment. This study investigates whether a type of brain scan called positron emission tomography (PET) can improve a physician s ability to diagnose FTD. This study will recruit patients who come to the University of Michigan Cognitive Disorders Clinic with symptoms of FTD. Each patient will have a study partner. Study partners must be 18 years or older, while patients will be adults 40 years or older. All subjects may be of any gender or race. Patients will have 4 outpatient study visits and a PET scan. The 4 study visits will occur over 18 months. At each research visit, patients will complete tests of thinking and behavior and be examined by a study physician. The PET scan involves inserting an intravenous catheter, receiving a small dose of a radiopharmaceutical, and lying on a table in the PET scanner for 30 minutes. Study partners will complete 2 surveys and accompany patients to all study visits. In addition, medical records from other evaluations will become part of study records.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。额颞叶痴呆症（FTD）是一种导致行为和思维进行性恶化的脑部疾病。目前很难准确诊断FTD，因为症状与其他疾病如阿尔茨海默病（AD）和抑郁症重叠。重要的是要能够区分这些条件，以提供最适当的咨询和治疗。这项研究调查了一种称为正电子发射断层扫描（PET）的大脑扫描是否可以提高医生诊断FTD的能力。这项研究将招募到密歇根大学认知障碍诊所的FTD症状患者。每例患者将有一名研究伴侣。研究伴侣必须年满18岁，而患者将是40岁或以上的成年人。所有受试者可以是任何性别或种族。患者将接受4次门诊研究访视和PET扫描。4次研究访视将在18个月内进行。在每次研究访视时，患者将完成思维和行为测试，并由研究医生进行检查。PET扫描包括插入静脉导管，接受小剂量的放射性药物，并躺在PET扫描仪的桌子上30分钟。研究合作伙伴将完成2项调查，并陪同患者参加所有研究访视。此外，其他评价的医疗记录将成为研究记录的一部分。