ALZHEIMER'S DISEASE NEUROIMAGING INITIATIVE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。目前，诊断阿尔茨海默病(AD)并准确预测其进展是很困难的。这项多中心研究将着眼于脑成像和其他生物测试(生物标记物)在检测AD及其进展中的有用性。参与者将包括患有以下疾病的老年人：1)早期AD，2)正常记忆和思维，或3)轻度认知障碍(MCI)，这是一种通常代表正常衰老和AD之间的过渡状态的情况。受试者将接受面谈和检查、认知测试和脑磁共振成像(MRI)，每隔大约6个月，为期2-3年。将采集血液和尿液样本。一部分受试者还将接受连续正电子发射断层扫描(PET)脑部成像。在研究期间，将从那些同意进行腰椎穿刺术的受试者身上收集两次脑脊液。从所有地点的参与者那里收集的信息和样本将被集中存储并提供给研究人员，以帮助研究人员设计未来治疗或预防阿尔茨海默病的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently, it is difficult to diagnose Alzheime's disease (AD) and predict its progression with certainty. This multicenter study will look at the usefulness of brain imaging and other biological tests (biomarkers) in detecting AD and its progression. Participants will include older adults with either: 1) early AD, 2) normal memory and thinking, or 3) mild cognitive impairment (MCI), a condition that often represents a transitional state between normal aging and AD. Subjects will undergo interviews and examinations, cognitive testing, and brain magnetic resonance imaging (MRI) at approximately 6-month intervals for 2-3 years. Blood and urine samples will be collected. A subset of subjects will also undergo serial positron emission tomography (PET) brain imaging. Cerebrospinal fluid will be collected twice during the study from those subjects agreeing to have a lumbar puncture. Information and samples collected from participants at all sites will be stored centrally and made available to help researchers design future studies to treat or prevent Alzheimer's disease.