ALENDRONATE VERSUS PLACEBO FOR OSTEOPENIA IN HIV

阿仑膦酸钠与安慰剂治疗 HIV 骨质减少症的比较

• 批准号: 7379343
• 负责人: Jeffrey Thomas Schouten
• 金额: $ 1.62万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379343
• 关键词: ALENDRONATE; VERSUS; PLACEBO; OSTEOPENIA; HIV

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A5163 is a phase II, randomized, double-blind, placebo-controlled study of the bisphosphonate alendronate for the treatment of HIV-associated decreased bone mineral density (BMD). 80 subjects (40 per arm, 27 female and 13 male in each) will receive blinded study treatment for 48 weeks, in addition to a calcium/vitamin D supplement. This study will examine the effect of weekly alendronate on lumbar spine and hip BMD in HIV-infected subjects receiving stable antiretroviral therapy (ART), in addition to daily calcium/vitamin D supplement. The study also will assess the safety and tolerability of alendronate in this population.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。A5163是一项II期、随机、双盲、安慰剂对照研究，研究双膦酸盐阿仑膦酸钠治疗hiv相关的骨密度降低（BMD）。80名受试者（每组40人，每组27名女性和13名男性）将接受为期48周的盲法研究治疗，同时补充钙/维生素D。本研究将检查每周服用阿仑膦酸钠对接受稳定抗逆转录病毒治疗（ART）的hiv感染者腰椎和髋部骨密度的影响，此外每日补充钙/维生素D。该研究还将评估阿仑膦酸钠在该人群中的安全性和耐受性。