ATENOLOL LACTATION STUDY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。高血压是孕妇的常见疾病。阿替洛尔是治疗妊娠期和妊娠期高血压的有效药物。我们最近完成了一项评估阿替洛尔在怀孕期间的药代动力学的研究。然而，还没有人研究阿替洛尔产后的药代动力学。阿替洛尔的产品标签上写道：“与血浆浓度相比，阿替洛尔在母乳中的排泄量为1.5：6.8。给哺乳妇女服用阿替洛尔时应格外小心。据报道，母乳喂养的婴儿出现了严重的心动过缓。早产儿或肾功能受损的婴儿更容易出现不良反应。”尽管有这一警告，许多接受阿替洛尔治疗高血压的妇女决定母乳喂养她们的婴儿。由于对婴儿有多种健康益处，美国儿科学会和世界卫生组织建议在婴儿出生后的前6个月进行纯母乳喂养。本研究旨在评价阿替洛尔在产后2~4周、3~4个月和6~8个月的血浆、尿液和母乳中的药代动力学。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. High blood pressure is a common condition in pregnant women. Atenolol is an effective agent for the management of high blood pressure during and after pregnancy. We recently completed a study evaluating the pharmacokinetics of atenolol in pregnancy. However, no one has studied the pharmacokinetics of atenolol postpartum. Product labeling for atenolol states that "Atenolol is excreted in human breast milk at a ratio of 1.5 to 6.8 when compared to the concentration in plasma. Caution should be exercised when atenolol is administered to a nursing woman. Clinically significant bradycardia has been reported in breast fed infants. Premature infants, or infants with impaired renal function, may be more likely to develop adverse effects." Despite this warning, many women receiving atenolol for hypertension decide to breastfeed their infants. Because of the multiple health benefits for infants, exclusive breastfeeding for the first 6 months of life is recommended by the American Academy of Pediatrics and the World Health Organization. This study is designed to evaluate the pharmacokinetics of atenolol in plasma, urine and breast milk 2-4 weeks, 3-4 months and 6-8 months postpartum in women taking atenolol for therapeutic reasons and nursing their infants.