A study on the role of polyunsaturated fatty acids during the murine lactation and the growth.

多不饱和脂肪酸在小鼠泌乳和生长过程中作用的研究。

• 批准号: 22500777
• 负责人: MORIGUCHI Toru
• 金额: $ 3万
• 依托单位: Azabu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500777/
• 关键词: 健康と食生活; 多価不飽和脂肪酸; マウス; 脳機能; 多価飽和脂肪酸; 神経科学; 栄養学

The aim of this experiment is the measurement of the dietary fatty acid composition in Δ6 desaturase knockout mice. D6D-null mice were fed n-3 adequate diet for 10 weeks from a young or adult age. Also we investigated the influence of fatty acid composition by n-3Adq milk in the newborn pups using artificial rearing technique. In the change of weight, we detected the significant decrease of body weight in young age and newborn lactation period, although there was no change in the adult age. Moreover, Arachidonic acid and docosahexaenoic acid significantly decreased in D6D Null mice. We think that there is a need to consider more about the function of these fatty acids.

本实验的目的是测量Δ6去饱和酶敲除小鼠中的膳食脂肪酸组成。从幼年或成年开始，对无D 6D的小鼠饲喂n-3充足饮食10周。此外，我们研究了脂肪酸组成的影响，n-3Adq牛奶在新生幼崽使用人工饲养技术。在体重变化方面，虽然成年期体重没有变化，但在幼年期和新生儿哺乳期体重明显下降。此外，花生四烯酸和二十二碳六烯酸在D 6D小鼠中显著降低。我们认为有必要更多地考虑这些脂肪酸的功能。