EPIDEMIOLOGY OF DIABETES INTERVENTIONS AND COMPLICATIONS (EDIC)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项长期的观察性研究继续检查1型糖尿病的并发症。它检查了与糖尿病的肾脏、大血管、眼睛和神经并发症的发展相关的因素。研究志愿者在1984至1993年间首次参与了糖尿病控制和并发症试验(DCCT)。每年进行一次探访，进行实验室和身体评估。眼睛检查，心脏和循环状态扫描，以及认知技能评估都是间歇性的。在接下来的两年里，将完成更详细的神经功能评估。到目前为止，已经发表了大量的文章。值得注意的是，这项研究引入了一个名为“代谢记忆”的概念，作为糖尿病并发症出现和进展差异的可能解释，尽管自DCCT完成以来，糖尿病并发症的出现和进展在最初的常规治疗组和强化治疗组之间仍然明显，尽管多年来血糖控制几乎相同。在一项联合研究中，我们从139名华盛顿大学DCCT/EDIC受试者的一级亲属那里获得了DNA、血液和尿液化学、血压和体型数据。正在与从其他EDIC诊所的亲属那里收集的样本一起进行分析。大多数亲属都是在GCRC上看到的，但其他人通过电话采访和在当地医生办公室进行的远程实验室测试参与其中。正在研究数据，以了解DCCT/EDIC受试者有或没有明显糖尿病并发症的家庭群体中出现的DNA共同点(如果有的话)。2002年9月至2004年8月期间，人们在GCRC上看到了他们的亲属

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This long-term observational study continues to examine complications of type 1 diabetes. It examines factors associated with development of kidney, macrovascular, eye and nerve complications of diabetes. Study volunteers first participated in the Diabetes Control and Complications Trial (DCCT), between 1984 and 1993. Visits occur annually, for laboratory and physical assessment. Eye exams, scans for cardiac and circulatory status, and evaluations of cognitive skills are included on an intermittent basis. Over the next two years, more detailed assessments of neurological function will be completed. Numerous articles have been published so far. Notably, this study has introduced a concept called "metabolic memory" as a possible explanation for differences in the appearance and progression of diabetes complications that are still evident between the original conventional and intensive treatment groups, despite years of nearly equal glucose control since DCCT completion. In an allied study, we obtained DNA, blood and urine chemistry, blood pressure, and body size data from 139 first-degree relatives of the University of Washington DCCT/EDIC subjects. This is being analyzed along with samples collected from relatives at other EDIC clinics. Most of the relatives were seen on the GCRC, but others participated through phone interview and "remote" lab tests at their local physicians' offices. Data is being studied to see what DNA commonalities, if any, appear among family groups where the DCCT/EDIC subject does or does not have significant complications of diabetes. The relatives were seen on the GCRC between September 2002 and August of 2004