Diabetes Endocrinology Research Center

总体描述（由申请人提供）： 华盛顿大学的糖尿病内分泌学研究中心（DERC）是全国16个糖尿病中心之一。华盛顿大学DERC的目标是：1）为附属研究者提供生物医学核心支持，2）为跨学科合作糖尿病研究创造环境并充当工具，3）赞助一项丰富计划，向糖尿病社区通报新进展，并刺激研究者的互动和合作，4）开展试点和可行性小额赠款计划，以支持新研究者的糖尿病研究，并为其他学科的既定研究者提供启动糖尿病项目的机制，5）开发新的研究方法和技术，并使糖尿病研究者能够使用这些方法和技术，6）作为大西雅图地区糖尿病研究活动的中心和保护伞。为了实现这些目标，DERC围绕七个核心单元组织起来：行政核心，细胞生物学核心，临床研究核心，细胞和分子成像核心，分子遗传学核心，质谱核心和胰岛细胞和功能分析核心。通过提供的特定服务，包括新的开发工作，这些核心支持大约95名附属研究者的研究。本研究涵盖了糖尿病研究的整个范围，包括a）1型糖尿病的病因和发病机制，B）2型糖尿病的病理生理学，c）肥胖和体重及成分的调节，d）临床试验和大规模流行病学研究，e）脂蛋白生理学和动脉粥样硬化，以及f）糖尿病和衰老的并发症。为了加强华盛顿大学糖尿病研究的科学环境并促进合作，DERC的丰富计划提供了一系列研讨会，年度核心研讨会和访问科学家计划。作为该中心致力于促进对糖尿病研究感兴趣的初级教师职业发展的一部分，DERC每年提供20万美元，用于支持糖尿病研究新研究人员的试点和可行性赠款。

DESCRIPTION, OVERALL (provided by applicant): The Diabetes Endocrinology Research Center (DERC) at the University of Washington is one of a total 16 Diabetes Centers nationwide. The objectives of the University of Washington DERC are to: 1) provide biomedical core support to Affiliate Investigators, 2) create an environment and serve as a vehicle for interdisciplinary collaborative diabetes research, 3) sponsor an enrichment program to inform the diabetes community of new developments, and to stimulate interaction and collaboration of investigators, 4) conduct a pilot and feasibility small grant program to support diabetes research by new investigators and to provide a mechanism for established investigators in other disciplines to initiate projects in diabetes, 5) develop new research methodologies and technologies and make these available to diabetes investigators, and 6) to serve as both a focal point and an umbrella for diabetes research activities in the greater Seattle area. To accomplish these goals, the DERC is organized around seven Core units: the Administrative Core, Cellular Biology Core, Clinical Research Core, Cellular and Molecular Imaging Core, Molecular Genetics Core, Mass Spectrometry Core, and the Islet Cell and Functional Analysis Core. Through specific services provided, including new developmental work, these Cores support the research of approximately 95 Affiliate Investigators. This research covers the entire spectrum of diabetes investigation including, a) etiology and pathogenesis of type 1 diabetes, b) pathophysiology of type 2 diabetes, c) obesity and regulation of bodyweight and composition, d) clinical trials and large-scale epidemiologic studies, e) lipoprotein physiology and atherosclerosis, and f) complications of diabetes and aging. To enhance the scientific environment for diabetes research at the University of Washington and to stimulate collaboration, the DERC's Enrichment Program provides a Seminar Series, an annual Core Symposium, and a Visiting Scientist Program. As part of the Center's commitment to fostering the career development of junior faculty interested in diabetes research, each year the DERC provides $200,000 to support pilot and feasibility grants of investigators new to diabetes research.