PHENOTYPING IMMUNE-BASED DEPRESSION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究将调查由用于治疗丙型肝炎感染的IFN-α的施用诱导的抑郁的生理学。一般的假设是，与两个对照组相比，在接受IFN-α治疗时发生抑郁症的患者将表现出夜间核心体温、基础代谢率、睡眠模式和细胞因子水平（IL-6、IL-1 a/B和TNF α）的变化：IFN-α治疗的丙型肝炎患者未发生抑郁症，丙型肝炎患者未发生抑郁症且未开始IFN-α治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will investigate the physiology of depression induced by administration of IFN-a for the treatment of hepatitis C infection. The general hypothesis is that patients who develop depression while receiving IFN-a will demonstrate changes in nighttime core body temperature, basal metabolic rate, sleep patterns, and cytokine levels (IL-6, IL-1a/b, and TNFa), when compared with two control groups: IFN-a treated hepatitis C patients who do not develop depression and hepatitis C patients who are without depression and have not been started on IFN-a.