Mechanisms of Meditation

冥想的机制

• 批准号: 7820780
• 负责人: Charles Raison
• 金额: $ 55.11万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7820780
• 关键词: Address; Adult; Affect; Age; American; Anger; Anxiety; Area; Attention; Behavior; Behavioral; Bite; Clinical Trials; Cognition; Collection; Compassion; Computers; Control Groups; Data; Distress; Dose; Education; Ego; Emotional; Emotions; Equipment; Evaluation; Event; Funding; Generations; Grant; Group Practice; Guidelines; Health; Health education; Hostility; Hour; Human Resources; Immune; Individual; Inflammatory; Inflammatory Response; Intervention; Intervention Studies; Laboratories; Language; Learning; Life; Life Style; Loneliness; Measures; Mediating; Meditation; Methodology; Molecular; Monitor; National Center for Complementary and Alternative Medicine; Nature; Neurosecretory Systems; Outcome; Outcome Measure; Parents; Patient Self-Report; Pattern; Peripheral; Persons; Phase; Physiological; Pilot Projects; Procedures; Protocols documentation; Psychosocial Stress; Public Health; Randomized; Recovery; Research; Sampling; Signal Pathway; Social Environment; Social support; Speech; Stress; Techniques; Testing; Time; Training; Trier Social Stress Test; United States National Institutes of Health; Wages; Well in self; active control; affiliative behavior; base; depression; design; fighting; improved; longitudinal design; mindfulness; novel; post intervention; psychosocial; public health relevance; response; satisfaction; secondary outcome; social integration; sound; stressor

DESCRIPTION (provided by applicant): This application is submitted in response to NOT-OD-09-058 "NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications". This supplement is intended to significantly expand the scope of our NCCAM-funded R01 Project entitled "Mechanisms of Meditation" (R01AT004698-01) by adding a completely novel methodology to assess whether different meditation practices have unique effects on naturalistic, real-world speech and behavior that is relevant to emotional well-being and positive psychosocial connectivity. This competitive supplement proposes an initial, but adequately powered, study to be completed in two years that addresses two inter-related priority areas of focus for NCCAM American Recovery and Reinvestment Act (RRA) funding, including: Novel and potentially richer secondary outcome measures Collection of additional data in ongoing clinical trials that will broaden the depth and/or scope of outcome measures. In keeping with NCCAM ARRA guidelines the bulk of requested funds will support new personnel for the project and/or will increase percent effort of key personnel to provide them salary support to devote time to the project expansion. As per guidelines, funding is also being requested for the purchase of computers and small equipment specifically required to conduct the competitive supplement protocol. In this supplement we propose to use the existing randomized, longitudinal, 3-group design of the Parent R01 to examine whether meditation affects real world, naturalistic speech and behavior in ways that-based on prior studies-would be expected to enhance emotional well being and health not just of the meditation practitioner but of other people in his or her social environment. In addition, a unique feature of the proposed project is that the Parent R01 design will allow for a comparison of two different meditation practices-compassion meditation and Mindful Attention Training (MAT)-in terms of effects on objective markers of individual emotional well-being and emotional stability, as well as on speech and behavior patterns known to promote positive psychosocial connectivity. In this regard, the current proposal may provide important new data on the potential of specific meditation techniques to improve public health via improved psychosocial functioning on the part of trained practitioners. Finally, this supplement will allow us to conduct the first ever examination of whether autonomic, neuroendocrine, innate immune and behavioral responses to a standardized laboratory psychosocial stressor (Trier Social Stress Test [TSST]) are associated with naturalistic language use and real world behavior. PUBLIC HEALTH RELEVANCE: This supplement application will expand the scope of our NCCAM-funded project entitled "Mechanisms of Meditation" by adding a novel methodology to assess whether different meditation practices have unique effects on naturalistic, real-world speech and behavior that is relevant to emotional well-being and positive psychosocial connectivity. Funds requested will support new personnel for the project and will increase percent effort of key personnel to provide them salary support to devote time to the project expansion. This supplement proposes an initial study that addresses two inter-related priority areas of focus for the American Recovery and Reinvestment Act (ARRA), including the enrichment of the original proposal with enhanced secondary outcome measures, and collection of additional data in ongoing clinical trials that will broaden the depth and/or scope of outcome measures.

描述(由申请人提供)：本申请是为了响应NOT-OD-09-058“NIH宣布恢复法资金可用于竞争性修订申请”而提交的。本附录旨在显著扩展我们由NCCAM资助的名为“冥想机制”(R01AT004698-01)的R01项目的范围，加入一种全新的方法来评估不同的冥想练习是否对与情绪健康和积极的心理社会联系相关的自然主义、真实世界的言语和行为产生独特的影响。这份竞争性补充文件建议在两年内完成一项初步的、但有足够动力的研究，解决NCCAM美国复苏和 再投资法案(RRA)资金，包括：新颖的和可能更丰富的次要结果衡量标准正在进行的临床试验中收集更多数据，这将扩大结果衡量标准的深度和/或范围。根据NCCAM ARRA指导方针，申请的大部分资金将支持项目的新人员和/或将增加关键人员的百分比努力，为他们提供工资支持，以便将时间用于项目扩展。根据指导方针，还要求提供资金，用于购买开展竞争性补充议定书特别需要的计算机和小型设备。在这份补充资料中，我们建议使用现有的随机、纵向、三组设计的父母R01来检验冥想是否影响现实世界、自然语言和行为-基于先前的研究-有望不仅提高冥想练习者的情绪健康，而且提高他或她的社会环境中其他人的情绪健康。此外，拟议项目的一个独特特点是，家长R01的设计将允许比较两种不同的冥想练习-同情冥想和正念注意力训练(MAT)-对个人情绪健康和情绪稳定性的客观标记物的影响，以及对已知的促进积极心理社会联系的言语和行为模式的影响。在这方面，目前的提案可能提供重要的新数据，说明特定冥想技术通过改善训练有素的从业者的心理社会功能来改善公共健康的潜力。最后，这一补充将使我们能够进行有史以来第一次检查自主神经、神经内分泌、先天免疫和对标准化实验室心理社会应激源(Trier Social Stress Test[TSST])的行为反应是否与自然语言使用和现实世界行为有关。 公共卫生相关性：这一补充申请将扩大我们由NCCAM资助的名为“冥想机制”的项目的范围，增加一种新的方法来评估不同的冥想练习是否对与情绪健康和积极的心理社会联系相关的自然主义、真实世界的言语和行为产生独特的影响。申请的资金将支持项目的新人员，并将增加关键人员的百分比努力，为他们提供工资支持，以便将时间用于项目扩展。本附录提出了一项初步研究，涉及美国复苏和再投资法案(ARRA)的两个相互关联的优先重点领域，包括用增强的次要结果衡量标准丰富原始提案，以及在正在进行的临床试验中收集额外数据，这将扩大结果衡量标准的深度和/或范围。