TREATMENT OF CYSTIC FIBROSIS PATIENTS WITH ANTIOXIDANT SOLUTION: A PILOT STUDY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。在囊性纤维化（CF）中，胰腺功能不全和胆汁酸池减少导致重要营养素和膳食成分吸收不良，导致营养状况不良和氧化应激。特别重要的是脂溶性营养素和抗氧化剂的吸收不良，这对正常的免疫和神经功能很重要。此外，这种吸收不良限制了CF患者对亲脂营养素和抗氧化剂（如必需脂肪酸、β -胡萝卜素和维生素E）的有效补充，而当这些营养素的补充水平高于从正常饮食中获得的水平时，可能会产生益处。可形成胶束状载体的口服液制剂可用于克服CF患者对这些营养物质的吸收不良。本研究将在20例CF患者中测试该配方在增加某些营养素和抗氧化剂的血浆水平方面的功效，并评估氧化应激参数的降低。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In cystic fibrosis (CF), pancreatic insufficiency and a diminished bile acid pool cause malabsorption of important nutrients and dietary components leading to poor nutritional status and oxidative stress. Of particular significance is the malabsorption of fat-soluble nutrients and antioxidants, which are important for normal immune and neurological function. Furthermore this malabsorption limits effective supplementation of CF patients with lipophilic nutrients and antioxidants such as essential fatty acids, beta-carotene and vitamin E, which may provide benefits when supplied at levels higher than those obtained from normal diets. An oral liquid formulation, which can form micelle-like vehicles, can be used to overcome the malabsorption of these nutrients in CF patients. This study will test the efficacy of this formulation in increasing the plasma levels of certain nutrients and antioxidants and evaluate the reduction in oxidative stress parameters in 20 patients with CF.