TREATMENT OF CYSTIC FIBROSIS PATIENTS WITH ANTIOXIDANT SOLUTION: A PILOT STUDY

使用抗氧化剂溶液治疗囊性纤维化患者：一项试点研究

• 批准号: 7374370
• 负责人: JEFFREY S WAGENER
• 金额: $ 0.59万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-24 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374370
• 关键词: antioxidants; malabsorption; oxidative stress; solutions

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In cystic fibrosis (CF), pancreatic insufficiency and a diminished bile acid pool cause malabsorption of important nutrients and dietary components leading to poor nutritional status and oxidative stress. Of particular significance is the malabsorption of fat-soluble nutrients and antioxidants, which are important for normal immune and neurological function. Furthermore this malabsorption limits effective supplementation of CF patients with lipophilic nutrients and antioxidants such as essential fatty acids, beta-carotene and vitamin E, which may provide benefits when supplied at levels higher than those obtained from normal diets. An oral liquid formulation, which can form micelle-like vehicles, can be used to overcome the malabsorption of these nutrients in CF patients. This study will test the efficacy of this formulation in increasing the plasma levels of certain nutrients and antioxidants and evaluate the reduction in oxidative stress parameters in 20 patients with CF.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。在囊性纤维化 (CF) 中，胰腺功能不全和胆汁酸池减少会导致重要营养素和膳食成分吸收不良，从而导致营养状况不佳和氧化应激。特别重要的是脂溶性营养素和抗氧化剂的吸收不良，这对正常的免疫和神经功能很重要。此外，这种吸收不良限制了 CF 患者有效补充亲脂性营养素和抗氧化剂，如必需脂肪酸、β-胡萝卜素和维生素 E，而这些营养素和抗氧化剂如果以高于正常饮食的水平提供，可能会带来益处。口服液体制剂可形成胶束样载体，可用于克服 CF 患者对这些营养素的吸收不良。本研究将测试该配方在增加某些营养素和抗氧化剂血浆水平方面的功效，并评估 20 名 CF 患者氧化应激参数的降低情况。