ASSESSMENT OF INDUCED SPUTUM TO EVAL ANTI-INFLAMMATORY AGENTS IN PTS W/CF

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Inflammatory contributes to the progression of cystic fibrosis (CF) lung disease. Anti-inflammatory therapy of corticosteroids in patients with CF have shown clinical benefit, but adverse effects have limited their use. Results from the clinical trials of alternate-day corticosteriods and high-dose ibuprofen in CF indicate anti-inflammatory therapy will slow the rate of decline. This study is a two arm, multicenter, randomized, open-label, controlled, parallel-group trial comparing the effects of 28 days of ibuprofen, or no treatment on inflammatory mediators in induced sputum in subjects with mild to moderate CF lung disease.