CYTOKINE LEVELS AND NEUTROPHIL PRIMING IN INFANTS WITH GASTROSCHISIS

腹裂婴儿的细胞因子水平和中性粒细胞启动

• 批准号: 7374403
• 负责人: Regina Reynolds
• 金额: $ 0.15万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-24 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374403
• 关键词: birth; blood; conflict; cord blood; cytokine; hospitals; necrotizing enterocolitis; neutrophil; surgery

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Infants with gastroschisis often have a prolonged hospital course involving feeding difficulties as well as other complications. Though many studies have looked at type of surgery and timing of repair, many of their results are conflicting. Few studies have looked at inflammatory markers in these infants to determine if they are predisposed to bowel dysfunction. Infants with inflammatory bowel dysfunction are prone to feeding intolerance, necrotizing enterocolitis, and need for further surgical intervention. In a pilot study, we propose to evaluate cord blood samples from infants with gastroschisis and compare them with blood samples from control infants without gastroschisis to determine if there are elevated levels of pro-inflammatory cytokines or evidence of neutrophil priming at birth. This would suggest that a pro-inflammatory state exists in utero and that could potentially identify infants predisposed to post inflammatory bowel dysfunction.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。患有腹裂的婴儿通常需要长时间的住院治疗，包括喂养困难以及其他并发症。虽然许多研究都着眼于手术类型和修复时间，但他们的许多结果是相互矛盾的。很少有研究关注这些婴儿的炎症标志物，以确定他们是否易患肠功能障碍。患有炎症性肠功能障碍的婴儿容易出现喂养不耐受、坏死性小肠结肠炎，并需要进一步手术干预。在一项初步研究中，我们建议评估腹裂婴儿的脐带血样本，并将其与无腹裂的对照婴儿的血液样本进行比较，以确定是否存在促炎细胞因子水平升高或出生时中性粒细胞引发的证据。这表明子宫内存在促炎状态，并且可能潜在地识别易患炎症后肠功能障碍的婴儿。