CONTINUOUS POSITIVE AIRWAY PRESSURE AND SUPERIOR MESENTERIC ARTERY BLOOD FLOW

持续气道正压和肠系膜上动脉血流

• 批准号: 7605124
• 负责人: Regina Reynolds
• 金额: $ 0.81万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605124
• 关键词: Abdomen; Affect; Air; Blood flow; Breathing; Computer Retrieval of Information on Scientific Projects Database; Continuous Positive Airway Pressure; Deglutition; Funding; Grant; Infant; Institution; Intestines; Measures; Necrotizing Enterocolitis; Nose; Premature Infant; Process; Research; Research Personnel; Resources; Risk; Secondary to; Source; Superior mesenteric artery structure; United States National Institutes of Health; Ventilator; design; feeding; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preterm infants not requiring a ventilator to breath are often placed on continuous positive airway pressure or CPAP to facilitate breathing. This apparatus delivers air flow through the nose and the air is therefore subject to be swallowed by the infant. Secondary to this process, infants receiving CPAP often demonstrate abdominal distention or "CPAP belly". It is unknown if this distention affects intestinal blood flow predisposing these infants to feeding intolerance and/or necrotizing enterocolitis. In this study we will evaluate the intestinal blood flow of preterm infants receiving CPAP and compare it to infants who are either mechanically ventilated or in room air. The blood flow will be measured prior to a feed and 45 minutes after a feed as intestinal blood flow should increase after feeding. By identifying a subset of infants with decreased intestinal blood flow in response to feeding, alternative feeding strategies would be designed to alleviate putting these infants at risk for feeding intolerance or intestinal damage.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 不需要呼吸机呼吸的早产儿通常置于持续气道正压或CPAP上以促进呼吸。 该装置通过鼻子输送空气流，因此空气易于被婴儿吞咽。 继发于该过程，接受CPAP的婴儿通常表现出腹胀或“CPAP腹部”。 目前尚不清楚这种膨胀是否会影响肠道血流，使这些婴儿易患喂养不耐受和/或坏死性小肠结肠炎。 在这项研究中，我们将评估接受CPAP治疗的早产儿的肠道血流，并将其与机械通气或室内空气的婴儿进行比较。 将在进食前和进食后45分钟测量血流量，因为进食后肠血流量应增加。 通过确定一个子集的婴儿减少肠道血流量响应喂养，替代喂养策略将被设计，以减轻这些婴儿喂养不耐受或肠道损伤的风险。