EVALUATION OF INFANTILE ACID AND NONACID GASTROESOPHAGEAL REFLUX

婴儿胃酸和非酸胃食管反流的评估

• 批准号: 7374358
• 负责人: JUDITH O'CONNOR
• 金额: $ 0.38万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-24 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374358
• 关键词: aging; diagnosis quality /standard; fluid; gold; reflux esophagitis; sleep

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Infantile reflux is common. The gold standard for the diagnosis of infantile gastroesophageal reflux (GER) has been intraesophageal pH monitoring. Intraluminal impedance monitoring is a new technique which measures fluid bolus movement independent of pH and offers an alternative mechanism to study GER. Evaluation of adults with GER utilizing combined multichannel intraluminal impedance (MII)/pH testing shows that acid and nonacid reflux events occur with equal frequency, 55% vs. 45% (1.2 to 1) compared with 15% vs. 85% (1 to 5.6) seen in the first studies in infants. Comparison of MII and pH probe monitoring demonstrated MII to be superior in the detection of reflux events, 96% vs. 28% respectively. Therefore, continuous impedance monitoring (6 hours) will better characterize infantile GER. Aim: The aim of this study is to redefine infantile GER in terms of acid and nonacid reflux episodes. Methods: Fifty infants, ages two weeks to one year, with symptomatic GER referred to the pediatric gastroenterology department will be enrolled in this study. The subjects will be admitted for a 20-hour continuous study undergoing simultaneous pH and multichannel intraluminal impedance (MII) testing. Evaluation: Tracings will be evaluated to identify the frequency and duration of both acid and nonacid reflux events during the pre-and-postprandial periods as well as during sleep.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。背景：婴儿反流是常见的。诊断婴儿胃食管反流（格尔）的金标准是食管内pH监测。管腔内阻抗监测是一种新技术，它测量不依赖于pH值的液体团运动，并提供了一种研究GER的替代机制。利用多通道管腔内阻抗（MII）/pH值联合检测对格尔成人进行评估，结果显示酸和非酸反流事件发生频率相同，55%与45%（1.2比1），而第一批婴儿研究中观察到的比例为15%与85%（1比5.6）。MII和pH探头监测的比较表明，MII在反流事件检测方面具有上级优势，分别为96%和28%。因此，连续阻抗监测（6小时）将更好地表征婴儿GER. Aim：本研究的目的是重新定义婴儿格尔的酸和非酸反流发作。研究方法：本研究将招募50名年龄为两周到一岁、患有症状性格尔综合征并转诊至儿科胃肠科的婴儿。受试者将接受20小时连续研究，同时进行pH和多通道腔内阻抗（MII）测试。评估：将对描记进行评价，以确定餐前和餐后以及睡眠期间酸反流和非酸反流事件的频率和持续时间。