SIBSHIP LINKAGE STUDY OF NON-MODULATION AND HYPERTENSION

非调节与高血压的同胞关系研究

• 批准号: 7376457
• 负责人: PAUL B HOPKINS
• 金额: $ 3.89万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376457
• 关键词: angiotensin II; blood pressure; hypertension; phenotype; siblings

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is designed to identify candidate genes for hypertension by extensively phenotyping siblings with hypertension and then looking for excess allele sharing among siblings with similar phenotypes. One such phenotype is non-modulation, a blunted response to infused angiotensin II on high and low salt diets. Other phenotypes may include salt sensitivity, low renin hypertension, urinary cortisol, and blood pressure response to angiotensin II infusion. We are also comparing intermediate phenotypes in hypertensive cases and normotensive controls.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究旨在通过对高血压同胞进行广泛的表型分型，然后在具有相似表型的同胞中寻找多余的等位基因共享，以确定高血压的候选基因。一种这样的表型是非调节，在高盐和低盐饮食中对输注的血管紧张素II的反应迟钝。其他表型可能包括盐敏感性、低血压、尿皮质醇和对血管紧张素II输注的血压反应。我们还比较了高血压病例和血压正常对照的中间表型。