Salt taste sensitivity, genetics and salt sensitivity of blood pressure in HIV
HIV 患者的盐味敏感性、遗传和血压盐敏感性
基本信息
- 批准号:10748253
- 负责人:
- 金额:$ 21.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-10 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectAfricaAfrica South of the SaharaAfricanAfrican ancestryAgeApplications GrantsAreaAutomobile DrivingBiological MarkersBlood PressureBlood specimenCardiovascular DiseasesCardiovascular systemCessation of lifeConsumptionCountryDataDevelopmentDiet HabitsDietary AssessmentEnzyme-Linked Immunosorbent AssayEthnic OriginEuropeanExhibitsFlow CytometryFoodFutureGeneticGenetic PolymorphismGenetic Predisposition to DiseaseGenetic RiskGenetic VariationGenetic studyGenomicsGenotypeGoalsHIVHIV SeronegativityHIV riskHourHypertensionIL17 geneIndividualInflammationInflammatoryInterferon Type IIInterleukin-6Intervention StudiesKidney DiseasesLaboratoriesLife StyleLinkLiteratureMeasuresMyocardial InfarctionParticipantPathogenesisPathologicPathway interactionsPerceptionPersonsPopulationPrevalenceProteomicsReceptor GeneRecommendationResearchRiskRisk FactorsSodium ChlorideStrokeTaste BudsTaste PerceptionTestingTongueUrineVascular DiseasesWorld Health OrganizationZambiaarterial stiffnessbiobankblood pressure elevationcohortdietary saltdisorder preventionepithelial Na+ channelgene productgenetic associationgenetic linkagegenetic varianthigh body mass indexhigh risk populationimmune activationinflammatory markerinsightlow and middle-income countriesmetabolomicsnormotensivepreferencerecruitresponsesaliva samplesalt intakesalt sensitive hypertension
项目摘要
Project Abstract
Hypertension is a risk factor for stroke, heart attack, kidney disease and death. Hypertension prevalence is high
in sub-Saharan Africa, specifically in persons living with HIV. Apart from traditional risk factors such as high body
mass index, age, immune activation and lifestyle, dietary salt is one of the driving factors contributing to the
development of hypertension directly by promoting pathological changes in the vasculature and indirectly through
immune activation and inflammation. Salt intake is driven mainly by salt taste sensitivity and specific genetic
variations in the taste receptor genes. High salt consumption is an independent predictor of hypertension, arterial
stiffness and cardiovascular disease. Salt consumption is generally high in Low- and Middle-Income Countries
including Zambia. The effects of salt on blood pressure (BP) are more pronounced in individuals with salt
sensitivity of blood pressure (SSBP). SSBP is when changes in BP mirror changes in dietary salt
intake/depletion. It is not clear if salt taste sensitivity correlates with SSBP. Furthermore, genetic variations in
the epithelial sodium channel (ENaC) in the tongue associated with salt taste sensitivity are unknown. Therefore,
the aims of this project are to: 1. To determine if salt taste sensitivity is associated with salt intake, SSBP and
inflammation in persons with HIV. We hypothesize that salt taste sensitivity correlates with SSBP and
inflammation. To achieve this, an existing cohort with known SSBP will be utilized and inflammatory biomarkers
measured using ELISA and flow cytometry, 24-hr food recall and 24-hour urine will be measured to assess
dietary salt intake. Salt taste sensitivity will be analysed using serial diluted salt solutions, and compared with
salt intake, SSBP and inflammation between people with and without HIV. Aim 2. To determine if genetic
variations in ENaC are associated with salt taste perception, SSBP and hypertension in HIV. We hypothesize
that specific genetic variations in the taste receptor genes particularly for ENaC are associated with salt taste,
SSBP and hypertension. To achieve this, genetic sequencing of taste receptor genes will be performed to
determine linkage with salt taste sensitivity and SSBP in persons with and without HIV. These studies will
generate hypotheses for future interventional studies. In addition, the long-term goal is to generate a biobank of
saliva and blood samples of persons from Africa for future genomic, proteomic and metabolomic analysis in an
R01 grant application.
项目摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Annet Kirabo其他文献
Annet Kirabo的其他文献
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{{ truncateString('Annet Kirabo', 18)}}的其他基金
Deep phenotypic and functional characterization of salt-responsive immune cells in human salt senstive hypertension using CTE-seq
使用 CTE-seq 对人类盐敏感性高血压中的盐反应性免疫细胞进行深度表型和功能表征
- 批准号:
10337042 - 财政年份:2021
- 资助金额:
$ 21.58万 - 项目类别:
Immune Mechanisms of Salt-Sensitive hypertension
盐敏感性高血压的免疫机制
- 批准号:
10401485 - 财政年份:2021
- 资助金额:
$ 21.58万 - 项目类别:
Immune Mechanisms of Salt-Sensitive hypertension
盐敏感性高血压的免疫机制
- 批准号:
10210910 - 财政年份:2021
- 资助金额:
$ 21.58万 - 项目类别:
Deep phenotypic and functional characterization of salt-responsive immune cells in human salt senstive hypertension using CTE-seq
使用 CTE-seq 对人类盐敏感性高血压中的盐反应性免疫细胞进行深度表型和功能表征
- 批准号:
10095170 - 财政年份:2021
- 资助金额:
$ 21.58万 - 项目类别:
Immune Mechanisms of Salt-Sensitive hypertension
盐敏感性高血压的免疫机制
- 批准号:
10613511 - 财政年份:2021
- 资助金额:
$ 21.58万 - 项目类别:
Enhancing parasympathetic activity to reduce vascular oxidative stress and endothelial dysfunction
增强副交感神经活性,减少血管氧化应激和内皮功能障碍
- 批准号:
10418658 - 财政年份:2021
- 资助金额:
$ 21.58万 - 项目类别:
Enhancing parasympathetic activity to reduce vascular oxidative stress and endothelial dysfunction
增强副交感神经活性,减少血管氧化应激和内皮功能障碍
- 批准号:
10625349 - 财政年份:2021
- 资助金额:
$ 21.58万 - 项目类别:
Role of Salt, Isoketal-modified Proteins and Dendritic Cells in Hypertension
盐、异缩酮修饰蛋白和树突状细胞在高血压中的作用
- 批准号:
9014703 - 财政年份:2016
- 资助金额:
$ 21.58万 - 项目类别:
ENaC regulation and its role in blood pressure homeostasis
ENaC 调节及其在血压稳态中的作用
- 批准号:
10338091 - 财政年份:1996
- 资助金额:
$ 21.58万 - 项目类别:
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