Salt taste sensitivity, genetics and salt sensitivity of blood pressure in HIV
HIV 患者的盐味敏感性、遗传和血压盐敏感性
基本信息
- 批准号:10748253
- 负责人:
- 金额:$ 21.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-10 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectAfricaAfrica South of the SaharaAfricanAfrican ancestryAgeApplications GrantsAreaAutomobile DrivingBiological MarkersBlood PressureBlood specimenCardiovascular DiseasesCardiovascular systemCessation of lifeConsumptionCountryDataDevelopmentDiet HabitsDietary AssessmentEnzyme-Linked Immunosorbent AssayEthnic OriginEuropeanExhibitsFlow CytometryFoodFutureGeneticGenetic PolymorphismGenetic Predisposition to DiseaseGenetic RiskGenetic VariationGenetic studyGenomicsGenotypeGoalsHIVHIV SeronegativityHIV riskHourHypertensionIL17 geneIndividualInflammationInflammatoryInterferon Type IIInterleukin-6Intervention StudiesKidney DiseasesLaboratoriesLife StyleLinkLiteratureMeasuresMyocardial InfarctionParticipantPathogenesisPathologicPathway interactionsPerceptionPersonsPopulationPrevalenceProteomicsReceptor GeneRecommendationResearchRiskRisk FactorsSodium ChlorideStrokeTaste BudsTaste PerceptionTestingTongueUrineVascular DiseasesWorld Health OrganizationZambiaarterial stiffnessbiobankblood pressure elevationcohortdietary saltdisorder preventionepithelial Na+ channelgene productgenetic associationgenetic linkagegenetic varianthigh body mass indexhigh risk populationimmune activationinflammatory markerinsightlow and middle-income countriesmetabolomicsnormotensivepreferencerecruitresponsesaliva samplesalt intakesalt sensitive hypertension
项目摘要
Project Abstract
Hypertension is a risk factor for stroke, heart attack, kidney disease and death. Hypertension prevalence is high
in sub-Saharan Africa, specifically in persons living with HIV. Apart from traditional risk factors such as high body
mass index, age, immune activation and lifestyle, dietary salt is one of the driving factors contributing to the
development of hypertension directly by promoting pathological changes in the vasculature and indirectly through
immune activation and inflammation. Salt intake is driven mainly by salt taste sensitivity and specific genetic
variations in the taste receptor genes. High salt consumption is an independent predictor of hypertension, arterial
stiffness and cardiovascular disease. Salt consumption is generally high in Low- and Middle-Income Countries
including Zambia. The effects of salt on blood pressure (BP) are more pronounced in individuals with salt
sensitivity of blood pressure (SSBP). SSBP is when changes in BP mirror changes in dietary salt
intake/depletion. It is not clear if salt taste sensitivity correlates with SSBP. Furthermore, genetic variations in
the epithelial sodium channel (ENaC) in the tongue associated with salt taste sensitivity are unknown. Therefore,
the aims of this project are to: 1. To determine if salt taste sensitivity is associated with salt intake, SSBP and
inflammation in persons with HIV. We hypothesize that salt taste sensitivity correlates with SSBP and
inflammation. To achieve this, an existing cohort with known SSBP will be utilized and inflammatory biomarkers
measured using ELISA and flow cytometry, 24-hr food recall and 24-hour urine will be measured to assess
dietary salt intake. Salt taste sensitivity will be analysed using serial diluted salt solutions, and compared with
salt intake, SSBP and inflammation between people with and without HIV. Aim 2. To determine if genetic
variations in ENaC are associated with salt taste perception, SSBP and hypertension in HIV. We hypothesize
that specific genetic variations in the taste receptor genes particularly for ENaC are associated with salt taste,
SSBP and hypertension. To achieve this, genetic sequencing of taste receptor genes will be performed to
determine linkage with salt taste sensitivity and SSBP in persons with and without HIV. These studies will
generate hypotheses for future interventional studies. In addition, the long-term goal is to generate a biobank of
saliva and blood samples of persons from Africa for future genomic, proteomic and metabolomic analysis in an
R01 grant application.
项目摘要
高血压是中风、心脏病、肾病和死亡的危险因素。高血压患病率高
在撒哈拉以南非洲地区,特别是艾滋病毒感染者。除了高身体等传统风险因素外
体重指数、年龄、免疫激活和生活方式,膳食盐是导致肥胖的驱动因素之一
高血压的发展直接通过促进脉管系统的病理变化而间接通过
免疫激活和炎症。盐的摄入量主要由盐味敏感性和特定遗传驱动
味觉受体基因的变异。高盐摄入量是高血压、动脉粥样硬化的独立预测因素
僵硬和心血管疾病。低收入和中等收入国家的食盐消费量普遍较高
包括赞比亚。盐对血压 (BP) 的影响在吃盐的个体中更为明显
血压敏感性(SSBP)。 SSBP 是指血压变化反映膳食盐的变化
摄入/消耗。目前尚不清楚盐味敏感性是否与 SSBP 相关。此外,遗传变异
与盐味敏感性相关的舌头上皮钠通道(ENaC)尚不清楚。所以,
该项目的目的是: 1. 确定盐味敏感性是否与盐摄入量、SSBP 和
HIV感染者的炎症。我们假设盐味敏感性与 SSBP 相关,并且
炎。为了实现这一目标,将利用已知 SSBP 的现有队列和炎症生物标志物
使用 ELISA 和流式细胞术进行测量,将测量 24 小时食物回忆和 24 小时尿液来评估
膳食盐摄入量。将使用连续稀释的盐溶液来分析盐味敏感性,并与
HIV感染者和未感染者之间的盐摄入量、SSBP和炎症。目标 2. 确定是否遗传
ENaC 的变化与 HIV 患者的盐味觉、SSBP 和高血压有关。我们假设
味觉受体基因(尤其是 ENaC)的特定遗传变异与盐味相关,
SSBP 和高血压。为了实现这一目标,将对味觉受体基因进行基因测序
确定感染和未感染艾滋病毒的人与盐味敏感性和 SSBP 的联系。这些研究将
为未来的介入研究提出假设。此外,长期目标是建立一个生物库
来自非洲的人的唾液和血液样本,用于未来的基因组、蛋白质组和代谢组分析
R01 拨款申请。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Annet Kirabo其他文献
Annet Kirabo的其他文献
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{{ truncateString('Annet Kirabo', 18)}}的其他基金
Deep phenotypic and functional characterization of salt-responsive immune cells in human salt senstive hypertension using CTE-seq
使用 CTE-seq 对人类盐敏感性高血压中的盐反应性免疫细胞进行深度表型和功能表征
- 批准号:
10337042 - 财政年份:2021
- 资助金额:
$ 21.58万 - 项目类别:
Immune Mechanisms of Salt-Sensitive hypertension
盐敏感性高血压的免疫机制
- 批准号:
10401485 - 财政年份:2021
- 资助金额:
$ 21.58万 - 项目类别:
Immune Mechanisms of Salt-Sensitive hypertension
盐敏感性高血压的免疫机制
- 批准号:
10210910 - 财政年份:2021
- 资助金额:
$ 21.58万 - 项目类别:
Deep phenotypic and functional characterization of salt-responsive immune cells in human salt senstive hypertension using CTE-seq
使用 CTE-seq 对人类盐敏感性高血压中的盐反应性免疫细胞进行深度表型和功能表征
- 批准号:
10095170 - 财政年份:2021
- 资助金额:
$ 21.58万 - 项目类别:
Immune Mechanisms of Salt-Sensitive hypertension
盐敏感性高血压的免疫机制
- 批准号:
10613511 - 财政年份:2021
- 资助金额:
$ 21.58万 - 项目类别:
Enhancing parasympathetic activity to reduce vascular oxidative stress and endothelial dysfunction
增强副交感神经活性,减少血管氧化应激和内皮功能障碍
- 批准号:
10418658 - 财政年份:2021
- 资助金额:
$ 21.58万 - 项目类别:
Enhancing parasympathetic activity to reduce vascular oxidative stress and endothelial dysfunction
增强副交感神经活性,减少血管氧化应激和内皮功能障碍
- 批准号:
10625349 - 财政年份:2021
- 资助金额:
$ 21.58万 - 项目类别:
Role of Salt, Isoketal-modified Proteins and Dendritic Cells in Hypertension
盐、异缩酮修饰蛋白和树突状细胞在高血压中的作用
- 批准号:
9014703 - 财政年份:2016
- 资助金额:
$ 21.58万 - 项目类别:
ENaC regulation and its role in blood pressure homeostasis
ENaC 调节及其在血压稳态中的作用
- 批准号:
10338091 - 财政年份:1996
- 资助金额:
$ 21.58万 - 项目类别:
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