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Salt taste sensitivity, genetics and salt sensitivity of blood pressure in HIV

HIV 患者的盐味敏感性、遗传和血压盐敏感性

基本信息

批准号：
10748253
负责人：
Annet Kirabo
金额：
$ 21.58万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-10 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10748253
关键词：
Address Adult Affect Africa Africa South of the Sahara African African ancestry Age Applications Grants Area Automobile Driving Biological Markers Blood Pressure Blood specimen Cardiovascular Diseases Cardiovascular system Cessation of life Consumption Country Data Development Diet Habits Dietary Assessment Enzyme-Linked Immunosorbent Assay Ethnic Origin European Exhibits Flow Cytometry Food Future Genetic Genetic Polymorphism Genetic Predisposition to Disease Genetic Risk Genetic Variation Genetic study Genomics Genotype Goals HIV HIV Seronegativity HIV risk Hour Hypertension IL17 gene Individual Inflammation Inflammatory Interferon Type II Interleukin-6 Intervention Studies Kidney Diseases Laboratories Life Style Link Literature Measures Myocardial Infarction Participant Pathogenesis Pathologic Pathway interactions Perception Persons Population Prevalence Proteomics Receptor Gene Recommendation Research Risk Risk Factors Sodium Chloride Stroke Taste Buds Taste Perception Testing Tongue Urine Vascular Diseases World Health Organization Zambia arterial stiffness biobank blood pressure elevation cohort dietary salt disorder prevention epithelial Na+ channel gene product genetic association genetic linkage genetic variant high body mass index high risk population immune activation inflammatory marker insight low and middle-income countries metabolomics normotensive preference recruit response saliva sample salt intake salt sensitive hypertension

项目摘要

Project Abstract Hypertension is a risk factor for stroke, heart attack, kidney disease and death. Hypertension prevalence is high in sub-Saharan Africa, specifically in persons living with HIV. Apart from traditional risk factors such as high body mass index, age, immune activation and lifestyle, dietary salt is one of the driving factors contributing to the development of hypertension directly by promoting pathological changes in the vasculature and indirectly through immune activation and inflammation. Salt intake is driven mainly by salt taste sensitivity and specific genetic variations in the taste receptor genes. High salt consumption is an independent predictor of hypertension, arterial stiffness and cardiovascular disease. Salt consumption is generally high in Low- and Middle-Income Countries including Zambia. The effects of salt on blood pressure (BP) are more pronounced in individuals with salt sensitivity of blood pressure (SSBP). SSBP is when changes in BP mirror changes in dietary salt intake/depletion. It is not clear if salt taste sensitivity correlates with SSBP. Furthermore, genetic variations in the epithelial sodium channel (ENaC) in the tongue associated with salt taste sensitivity are unknown. Therefore, the aims of this project are to: 1. To determine if salt taste sensitivity is associated with salt intake, SSBP and inflammation in persons with HIV. We hypothesize that salt taste sensitivity correlates with SSBP and inflammation. To achieve this, an existing cohort with known SSBP will be utilized and inflammatory biomarkers measured using ELISA and flow cytometry, 24-hr food recall and 24-hour urine will be measured to assess dietary salt intake. Salt taste sensitivity will be analysed using serial diluted salt solutions, and compared with salt intake, SSBP and inflammation between people with and without HIV. Aim 2. To determine if genetic variations in ENaC are associated with salt taste perception, SSBP and hypertension in HIV. We hypothesize that specific genetic variations in the taste receptor genes particularly for ENaC are associated with salt taste, SSBP and hypertension. To achieve this, genetic sequencing of taste receptor genes will be performed to determine linkage with salt taste sensitivity and SSBP in persons with and without HIV. These studies will generate hypotheses for future interventional studies. In addition, the long-term goal is to generate a biobank of saliva and blood samples of persons from Africa for future genomic, proteomic and metabolomic analysis in an R01 grant application.

项目摘要