OXIDATIVE STRESS IN AORTIC ANEURYSM

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Abdominal aortic aneurysms (AAA) occur in up to 9% of persons >65 years of age. Surgical techniques to repair AAA carry significant risks, and there is no particularly effective medical therapy. The highly inflammatory nature of AAA leads to (1) an increase in the formation of ROS, and (2) a decrease in the levels of protective antioxidants in these patients. These findings suggest that oxidative stress is enhanced and may play a role in the pathogenesis of AAA in humans. While our long-term hypothesis is that effective antioxidant therapy can attenuate AAA growth and its consequences (i.e., rupture) in patients with AAA, the purpose of this pilot project is to identify a clinically effective antioxidant regimen that reduces oxidative stress in AAA patients.