BACTEREMIA IN SUBJECTS WITH LIVER DISEASE COMPARED TO OTHER CHRONIC ILLNESS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It has been shown that liver failure is associated with poor prognosis in patients with sepsis. The liver participates in bacterial clearance via the reticular-endothelial system. In addition, Kupffer cells are an important source of cytokines during systemic infection. Our animal data suggests that the degree of liver injury (manifest as level of ALT) in a murine model of pneumonia and sepsis correlates with the level of systemic bacteremia. In addition, as the levels of systemic bacteremia increase, the mortality increases as well. Therefore, we hypothesize that liver disease is associated with decreased bacterial clearance which results in increased bacteremia.